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Long-term hyperuricemia impact on atrial fibrillation outcomes
No studies have been conducted to analyze the impact of serum uric acid (UA) levels on the outcome of atrial fibrillation (AF) patients. We aimed to evaluate the effect of hyperuricemia (HU) on the prognosis of AF. Consecutive patients who consulted our emergency room for an episode of AF, already k...
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| Published in: | Current problems in cardiology 2024-07, Vol.49 (7), p.102608-102608, Article 102608 |
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| container_title | Current problems in cardiology |
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| creator | Quesada, Aurelio Quesada-Ocete, Javier Quesada-Ocete, Blanca González-Ritonnale, Adrian Marcaida-Benito, Goizane Moral- Ronda, Víctor del Jiménez-Bello, Javier Sahuquillo-Frias, Laura Rubini-Costa, Ricardo Lavie, Carl J. Morin, Daniel P. Guía-Galipienso, Fernando de la Rubini-Puig, Ricardo Sanchis-Gomar, Fabian |
| description | No studies have been conducted to analyze the impact of serum uric acid (UA) levels on the outcome of atrial fibrillation (AF) patients. We aimed to evaluate the effect of hyperuricemia (HU) on the prognosis of AF.
Consecutive patients who consulted our emergency room for an episode of AF, already known or newly diagnosed, between January 1, 2010, and December 31, 2015 (n=2017) were enrolled. After applying exclusion criteria, 1772 patients were included. Serum UA levels in the 6 months before or after the date of the episode were recorded and classified into quartiles: Q1 (n=443) serum UA levels |
| doi_str_mv | 10.1016/j.cpcardiol.2024.102608 |
| format | article |
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Consecutive patients who consulted our emergency room for an episode of AF, already known or newly diagnosed, between January 1, 2010, and December 31, 2015 (n=2017) were enrolled. After applying exclusion criteria, 1772 patients were included. Serum UA levels in the 6 months before or after the date of the episode were recorded and classified into quartiles: Q1 (n=443) serum UA levels <4.6 mg/dL; Q2 (n=430) 4.6-5.6 mg/dL; Q3 (n=435) 5.7-6.9 mg/dL; and Q4 (n=464) ≥7 mg/dL. Two groups were differentiated: patients without HU (Q1-Q3) and those with HU (Q4). The mean follow-up was 3.7 ± 1.4 years. The primary endpoint was all-cause mortality during follow-up. Mortality during follow-up in the bivariate analysis was higher (p < 0.001) in patients with HU (52.1 %) compared to those without it (35.3 %), confirming multivariate Cox analysis of HU as an independent risk factor for death [hazard ratio 1.89 (1.59-2.25)]. Kaplan-Meier survival analysis showed a shorter survival time in patients with HU (log-rank test, p<0.001). Cox analysis confirmed significant differences in the risk of heart failure (30 % vs. 22 %) in patients with HU.
HU is independently associated with an increased risk for all-cause mortality and hospitalization for heart failure in patients with AF.</description><identifier>ISSN: 0146-2806</identifier><identifier>EISSN: 1535-6280</identifier><identifier>DOI: 10.1016/j.cpcardiol.2024.102608</identifier><identifier>PMID: 38697331</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Atrial Fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - epidemiology ; Biomarkers - blood ; Cause of Death - trends ; Female ; Follow-Up Studies ; Heart Failure ; Hospitalization ; Humans ; Hyperuricemia - blood ; Hyperuricemia - complications ; Hyperuricemia - epidemiology ; Male ; Middle Aged ; Morbidity ; Mortality ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival ; Survival Rate - trends ; Time Factors ; Uric Acid ; Uric Acid - blood</subject><ispartof>Current problems in cardiology, 2024-07, Vol.49 (7), p.102608-102608, Article 102608</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-771aa04b245bf41ee8701bdc2d02e6d6b5fa614fb1b6fe5afd48c4452c6e3d2b3</citedby><cites>FETCH-LOGICAL-c371t-771aa04b245bf41ee8701bdc2d02e6d6b5fa614fb1b6fe5afd48c4452c6e3d2b3</cites><orcidid>0000-0003-0424-4208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38697331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quesada, Aurelio</creatorcontrib><creatorcontrib>Quesada-Ocete, Javier</creatorcontrib><creatorcontrib>Quesada-Ocete, Blanca</creatorcontrib><creatorcontrib>González-Ritonnale, Adrian</creatorcontrib><creatorcontrib>Marcaida-Benito, Goizane</creatorcontrib><creatorcontrib>Moral- Ronda, Víctor del</creatorcontrib><creatorcontrib>Jiménez-Bello, Javier</creatorcontrib><creatorcontrib>Sahuquillo-Frias, Laura</creatorcontrib><creatorcontrib>Rubini-Costa, Ricardo</creatorcontrib><creatorcontrib>Lavie, Carl J.</creatorcontrib><creatorcontrib>Morin, Daniel P.</creatorcontrib><creatorcontrib>Guía-Galipienso, Fernando de la</creatorcontrib><creatorcontrib>Rubini-Puig, Ricardo</creatorcontrib><creatorcontrib>Sanchis-Gomar, Fabian</creatorcontrib><title>Long-term hyperuricemia impact on atrial fibrillation outcomes</title><title>Current problems in cardiology</title><addtitle>Curr Probl Cardiol</addtitle><description>No studies have been conducted to analyze the impact of serum uric acid (UA) levels on the outcome of atrial fibrillation (AF) patients. We aimed to evaluate the effect of hyperuricemia (HU) on the prognosis of AF.
Consecutive patients who consulted our emergency room for an episode of AF, already known or newly diagnosed, between January 1, 2010, and December 31, 2015 (n=2017) were enrolled. After applying exclusion criteria, 1772 patients were included. Serum UA levels in the 6 months before or after the date of the episode were recorded and classified into quartiles: Q1 (n=443) serum UA levels <4.6 mg/dL; Q2 (n=430) 4.6-5.6 mg/dL; Q3 (n=435) 5.7-6.9 mg/dL; and Q4 (n=464) ≥7 mg/dL. Two groups were differentiated: patients without HU (Q1-Q3) and those with HU (Q4). The mean follow-up was 3.7 ± 1.4 years. The primary endpoint was all-cause mortality during follow-up. Mortality during follow-up in the bivariate analysis was higher (p < 0.001) in patients with HU (52.1 %) compared to those without it (35.3 %), confirming multivariate Cox analysis of HU as an independent risk factor for death [hazard ratio 1.89 (1.59-2.25)]. Kaplan-Meier survival analysis showed a shorter survival time in patients with HU (log-rank test, p<0.001). Cox analysis confirmed significant differences in the risk of heart failure (30 % vs. 22 %) in patients with HU.
HU is independently associated with an increased risk for all-cause mortality and hospitalization for heart failure in patients with AF.</description><subject>Aged</subject><subject>Atrial Fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Biomarkers - blood</subject><subject>Cause of Death - trends</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Failure</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hyperuricemia - blood</subject><subject>Hyperuricemia - complications</subject><subject>Hyperuricemia - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>Uric Acid</subject><subject>Uric Acid - blood</subject><issn>0146-2806</issn><issn>1535-6280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkElPwzAQhS0EoqXwFyBHLine4qQXpKpikypxgbPlZQKukjjYDlL_PalSuHKa0dN7s3wI3RC8JJiIu93S9EYF63yzpJjyUaUCVydoTgpW5IJW-BTNMeEiH1sxQxcx7jAmdEXEOZqxSqxKxsgc3W9995EnCG32ue8hDMEZaJ3KXNsrkzLfZSoFp5qsdjq4plHJjZofkvEtxEt0VqsmwtWxLtD748Pb5jnfvj69bNbb3LCSpLwsiVKYa8oLXXMCUJWYaGuoxRSEFbqolSC81kSLGgpVW14ZzgtqBDBLNVug22luH_zXADHJ1kUD4zkd-CFKhgu8YivG-GgtJ6sJPsYAteyDa1XYS4LlAZ7cyT948gBPTvDG5PVxyaBbsH-5X1qjYT0ZYHz120GQ0TjoDFgXwCRpvft3yQ8li4VE</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Quesada, Aurelio</creator><creator>Quesada-Ocete, Javier</creator><creator>Quesada-Ocete, Blanca</creator><creator>González-Ritonnale, Adrian</creator><creator>Marcaida-Benito, Goizane</creator><creator>Moral- Ronda, Víctor del</creator><creator>Jiménez-Bello, Javier</creator><creator>Sahuquillo-Frias, Laura</creator><creator>Rubini-Costa, Ricardo</creator><creator>Lavie, Carl J.</creator><creator>Morin, Daniel P.</creator><creator>Guía-Galipienso, Fernando de la</creator><creator>Rubini-Puig, Ricardo</creator><creator>Sanchis-Gomar, Fabian</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0424-4208</orcidid></search><sort><creationdate>202407</creationdate><title>Long-term hyperuricemia impact on atrial fibrillation outcomes</title><author>Quesada, Aurelio ; Quesada-Ocete, Javier ; Quesada-Ocete, Blanca ; González-Ritonnale, Adrian ; Marcaida-Benito, Goizane ; Moral- Ronda, Víctor del ; Jiménez-Bello, Javier ; Sahuquillo-Frias, Laura ; Rubini-Costa, Ricardo ; Lavie, Carl J. ; Morin, Daniel P. ; Guía-Galipienso, Fernando de la ; Rubini-Puig, Ricardo ; Sanchis-Gomar, Fabian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-771aa04b245bf41ee8701bdc2d02e6d6b5fa614fb1b6fe5afd48c4452c6e3d2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Atrial Fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Biomarkers - blood</topic><topic>Cause of Death - trends</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Failure</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hyperuricemia - blood</topic><topic>Hyperuricemia - complications</topic><topic>Hyperuricemia - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Survival</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>Uric Acid</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quesada, Aurelio</creatorcontrib><creatorcontrib>Quesada-Ocete, Javier</creatorcontrib><creatorcontrib>Quesada-Ocete, Blanca</creatorcontrib><creatorcontrib>González-Ritonnale, Adrian</creatorcontrib><creatorcontrib>Marcaida-Benito, Goizane</creatorcontrib><creatorcontrib>Moral- Ronda, Víctor del</creatorcontrib><creatorcontrib>Jiménez-Bello, Javier</creatorcontrib><creatorcontrib>Sahuquillo-Frias, Laura</creatorcontrib><creatorcontrib>Rubini-Costa, Ricardo</creatorcontrib><creatorcontrib>Lavie, Carl J.</creatorcontrib><creatorcontrib>Morin, Daniel P.</creatorcontrib><creatorcontrib>Guía-Galipienso, Fernando de la</creatorcontrib><creatorcontrib>Rubini-Puig, Ricardo</creatorcontrib><creatorcontrib>Sanchis-Gomar, Fabian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current problems in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quesada, Aurelio</au><au>Quesada-Ocete, Javier</au><au>Quesada-Ocete, Blanca</au><au>González-Ritonnale, Adrian</au><au>Marcaida-Benito, Goizane</au><au>Moral- Ronda, Víctor del</au><au>Jiménez-Bello, Javier</au><au>Sahuquillo-Frias, Laura</au><au>Rubini-Costa, Ricardo</au><au>Lavie, Carl J.</au><au>Morin, Daniel P.</au><au>Guía-Galipienso, Fernando de la</au><au>Rubini-Puig, Ricardo</au><au>Sanchis-Gomar, Fabian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term hyperuricemia impact on atrial fibrillation outcomes</atitle><jtitle>Current problems in cardiology</jtitle><addtitle>Curr Probl Cardiol</addtitle><date>2024-07</date><risdate>2024</risdate><volume>49</volume><issue>7</issue><spage>102608</spage><epage>102608</epage><pages>102608-102608</pages><artnum>102608</artnum><issn>0146-2806</issn><eissn>1535-6280</eissn><abstract>No studies have been conducted to analyze the impact of serum uric acid (UA) levels on the outcome of atrial fibrillation (AF) patients. We aimed to evaluate the effect of hyperuricemia (HU) on the prognosis of AF.
Consecutive patients who consulted our emergency room for an episode of AF, already known or newly diagnosed, between January 1, 2010, and December 31, 2015 (n=2017) were enrolled. After applying exclusion criteria, 1772 patients were included. Serum UA levels in the 6 months before or after the date of the episode were recorded and classified into quartiles: Q1 (n=443) serum UA levels <4.6 mg/dL; Q2 (n=430) 4.6-5.6 mg/dL; Q3 (n=435) 5.7-6.9 mg/dL; and Q4 (n=464) ≥7 mg/dL. Two groups were differentiated: patients without HU (Q1-Q3) and those with HU (Q4). The mean follow-up was 3.7 ± 1.4 years. The primary endpoint was all-cause mortality during follow-up. Mortality during follow-up in the bivariate analysis was higher (p < 0.001) in patients with HU (52.1 %) compared to those without it (35.3 %), confirming multivariate Cox analysis of HU as an independent risk factor for death [hazard ratio 1.89 (1.59-2.25)]. Kaplan-Meier survival analysis showed a shorter survival time in patients with HU (log-rank test, p<0.001). Cox analysis confirmed significant differences in the risk of heart failure (30 % vs. 22 %) in patients with HU.
HU is independently associated with an increased risk for all-cause mortality and hospitalization for heart failure in patients with AF.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>38697331</pmid><doi>10.1016/j.cpcardiol.2024.102608</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0424-4208</orcidid></addata></record> |
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| ispartof | Current problems in cardiology, 2024-07, Vol.49 (7), p.102608-102608, Article 102608 |
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| subjects | Aged Atrial Fibrillation Atrial Fibrillation - complications Atrial Fibrillation - epidemiology Biomarkers - blood Cause of Death - trends Female Follow-Up Studies Heart Failure Hospitalization Humans Hyperuricemia - blood Hyperuricemia - complications Hyperuricemia - epidemiology Male Middle Aged Morbidity Mortality Prognosis Retrospective Studies Risk Factors Survival Survival Rate - trends Time Factors Uric Acid Uric Acid - blood |
| title | Long-term hyperuricemia impact on atrial fibrillation outcomes |
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