Long term impact of transjugular intrahepatic portosystemic shunt (TIPS) creation on hepatic morphology

The purpose of this study was to evaluate long-term morphologic changes occurring in the liver after TIPS creation with correlation with hepatic function to gain insight on the physiologic impact of TIPS on the liver. This retrospective study included patients who underwent TIPS creation between 200...

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Bibliographic Details
Published in:Clinical imaging 2024-06, Vol.110, p.110142-110142, Article 110142
Main Authors: Gupta, Vikram F., Benvenuti, Teresa, Ronald, James, Cline, Brendan C., Befera, Nicholas T., Martin, Jonathan G., Pabon-Ramos, Waleska M., Sag, Alan A., Smith, Tony P., Suhocki, Paul V., Kim, Charles Y.
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Hepatic morphology
Hepatic vein thrombosis
Humans
Liver - diagnostic imaging
Liver - surgery
Magnetic Resonance Imaging - methods
Male
MELD
Middle Aged
Portal vein
Portasystemic Shunt, Transjugular Intrahepatic
Retrospective Studies
Tomography, X-Ray Computed
Transjugular intrahepatic portosystemic shunt
Treatment Outcome
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Summary:The purpose of this study was to evaluate long-term morphologic changes occurring in the liver after TIPS creation with correlation with hepatic function to gain insight on the physiologic impact of TIPS on the liver. This retrospective study included patients who underwent TIPS creation between 2005 and 2022 and had contrasted CT or MRI studies prior to and between 1 and 2 years post procedure. Strict exclusion criteria were applied to avoid confounding. Parenchymal volume and vessel measurements were assessed on the pre- and post-TIPS CT or MRI and MELD scores calculated. Of 580 patients undergoing TIPS creation, 65 patients (mean age, 55 years; 36 males) had pre-TIPS and post-TIPS imaging meeting inclusion criteria at median 16.5 months. After TIPS, the mean MELD score increased (12.9 to 15.4; p = 0.008) and total liver volume decreased (1730 to 1432 mL; p 
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2024.110142