An electrochemical sensor based on molecularly imprinted poly(o-phenylenediamine) for the detection of thymol

• Published in: Analytical biochemistry 2024-08, Vol.691, p.115551-115551, Article 115551
• Main Authors: Dong, Jieming, Zhang, Hongyu, Ding, Zhixiang, Li, Junyao, Xu, Laidi, Kong, Yong, Zheng, Guojun
• Format: Article
• Language: English
• Subjects: Electrochemical polymerization; Electrochemical sensors; Molecular imprinting; Poly(o-phenylenediamine); Thymol
• ISSN: 0003-2697; 1096-0309
• DOI: 10.1016/j.ab.2024.115551

A molecularly imprinted electrochemical sensor was facilely fabricated for the detection of thymol (THY). o-Phenylenediamine (oPD) was used as the functional monomer and electropolymerized on the surface of the glassy carbon electrode (GCE) by using THY as the templates. After the THY templates were removed with 50 % (v/v) ethanol, imprinted cavities complementary to the templates were formed within the poly(o-phenylenediamine) (PoPD) films. The resultant molecularly imprinted PoPD/GCE (MI-PoPD/GCE) was used for the detection of THY, and a wide linear range from 0.5 to 100 μM with a low limit of detection (LOD) of 0.084 μM were obtained under the optimal conditions. The developed MI-PoPD/GCE also displays high selectivity, reproducibility and stability for THY detection. Finally, the content of THY in the real samples was accurately determined by the as-fabricated MI-PoPD/GCE, demonstrating its high practicability and reliability. [Display omitted] •A molecularly imprinted electrochemical sensor is designed for the detection of THY.•oPD is electropolymerized on the surface of GCE by using THY as the templates.•Imprinted cavities are formed in the PoPD films after the removal of the templates.•The MI-PoPD/GCE is used for THY detection with a wide linear range and a low LOD.•The reliability of the sensor is demonstrated by the detection of THY in real sample.