Integrative Clinical, Hormonal and Molecular Data associate with Invasiveness in Acromegaly: REMAH Study

Growth-hormone (GH)-secreting pituitary-tumors (GHomas) are the most common acromegaly cause. At diagnosis, most of them are macroadenomas, and up to 56% display cavernous sinus invasion. Biomarkers assessment associated with tumor-growth and invasion are important to optimize their management. To i...

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Published in:European journal of endocrinology 2024-06, Vol.190 (6), p.421-433
Main Authors: Sampedro-Nuñez, Miguel, Herrera-Martínez, Aura Dulcinea, Ibáñez-Costa, Alejandro, Rivero-Cortés, Esther, Venegas, Eva, Robledo, Mercedes, Martínez-Hernández, Rebeca, García-Martínez, Araceli, Gil, Joan, Jordà, Mireia, López-Fernández, Judith, Gavilán, Inmaculada, Maraver, Silvia, Marqués-Pamies, Montserrat, Cámara, Rosa, Fajardo-Montañana, Carmen, Valassi, Elena, Dios, Elena, Aulinas, Anna, Biagetti, Betina, Álvarez Escola, Cristina, Araujo-Castro, Marta, Blanco, Concepción, de Miguel, Paz, Villar-Taibo, Rocío, Álvarez, Clara V, Gaztambide, Sonia, Webb, Susan M, Castaño, Luis, Bernabéu, Ignacio, Picó, Antonio, Gálvez, María-Ángeles, Soto-Moreno, Alfonso, Puig-Domingo, Manel, Castaño, Justo P, Marazuela, Mónica, Luque, Raúl M
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Language:English
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Summary:Growth-hormone (GH)-secreting pituitary-tumors (GHomas) are the most common acromegaly cause. At diagnosis, most of them are macroadenomas, and up to 56% display cavernous sinus invasion. Biomarkers assessment associated with tumor-growth and invasion are important to optimize their management. To identify clinical/hormonal/molecular-biomarkers associated with tumor-size and invasiveness in GHomas, and to analyze the influence of pre-treatment with somatostatin-analogs or dopamine-agonists in key molecular biomarkers expression. Clinical/analytical/radiological-variables were evaluated in 192 patients from the REMAH-study (ambispective multicenter post-surgery study of the Spanish Society of Endocrinology and Nutrition). Expression of somatostatin/ghrelin/dopamine-systems components, and key pituitary/proliferation-markers were evaluated in GHomas after the first surgery. Univariate/multivariate regression studies were performed to identify association between variables. 80% of patients harbor macroadenomas (63.8% with extrasellar-growth). Associations between larger and more invasive GHomas with younger age, visual-abnormalities, higher IGF1-levels, extrasellar/suprasellar-growth and/or cavernous-sinus invasion were found. Higher GH1 and lower PRL/POMC/CGA/AVPR1B/DRD2T/DRD2L expression levels (p
ISSN:0804-4643
1479-683X
1479-683X
DOI:10.1093/ejendo/lvae045