Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study

• Published in: Journal of magnetic resonance imaging 2025-01, Vol.61 (1), p.321-334
• Main Authors: Li, Xue‐Ming, Shi, Rui, Shen, Meng‐Ting, Yan, Wei‐Feng, Jiang, Li, Min, Chen‐Yan, Liu, Xiao‐Jing, Guo, Ying‐Kun, Yang, Zhi‐Gang
• Format: Article
• Language: English
• Subjects: Abnormalities; Adult; Aged; Atria; Circumferences; Correlation coefficient; Correlation coefficients; Coupling; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - physiopathology; Essential Hypertension - complications; Essential Hypertension - diagnostic imaging; Essential Hypertension - physiopathology; Female; Field strength; Heart; Heart Atria - diagnostic imaging; Heart Atria - physiopathology; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Humans; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - physiopathology; left atrium; left ventricle; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging, Cine - methods; Male; Males; Middle Aged; Multivariable control; Population studies; Regression analysis; Retrospective Studies; Statistical analysis; Statistical tests; strain; Strain rate; Structure-function relationships; type 2 diabetes mellitus; Variance analysis; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.29427

Background Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear. Purpose To identify differences between hypertensive patients with and without T2DM as the basis for further investigation the atrioventricular coupling relationship. Study Type Cross‐sectional, retrospective study. Population 89 hypertensive patients without T2DM [HTN (T2DM−)] (age: 58.4 +/− 11.9 years, 48 male), 62 hypertensive patients with T2DM [HTN (T2DM+)] (age: 58.5 +/− 9.1 years, 32 male) and 70 matched controls (age: 55.0 +/− 9.6 years, 37 male). Field Strength/Sequence 2D balanced steady‐state free precession cine sequence at 3.0 T. Assessment LA reservoir, conduit, and booster strain (εs, εe, and εa) and strain rate (SRs, SRe, and SRa), LV radial, circumferential and longitudinal peak strain (PS) and peak systolic strain rate and peak diastolic strain rate (PSSR and PDSR) were derived from LA and LV cine images and compared between groups. Statistical Tests Chi‐square or Fisher's exact test, one‐way analysis of variance, analysis of covariance, Pearson's correlation, multivariable linear regression analysis, and intraclass correlation coefficient. A P value