Age-specific mortality trends in heart failure over 25 years: a retrospective Danish nationwide cohort study

Despite advances in heart failure care reducing mortality in clinical trials, it remains unclear whether real-life cohorts have had similar improvements in life expectancy across the age spectrum. We aimed to investigate how mortality trends changed in patients with heart failure over the past 25 ye...

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Published in:The Lancet. Healthy longevity 2024-05, Vol.5 (5), p.e326-e335
Main Authors: Garred, Caroline Hartwell, Malmborg, Morten, Malik, Mariam Elmegaard, Zahir, Deewa, Christensen, Daniel Mølager, Arulmurugananthavadivel, Anojhaan, Fosbøl, Emil L, Gislason, Gunnar, McMurray, John J V, Petrie, Mark C, Andersson, Charlotte, Køber, Lars, Schou, Morten
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Denmark - epidemiology
Female
Heart Failure - mortality
Humans
Male
Middle Aged
Registries
Retrospective Studies
Young Adult
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Summary:Despite advances in heart failure care reducing mortality in clinical trials, it remains unclear whether real-life cohorts have had similar improvements in life expectancy across the age spectrum. We aimed to investigate how mortality trends changed in patients with heart failure over the past 25 years, stratified by age groups. Using Danish nationwide registries, we identified patients with new-onset heart failure aged 18–95 years. The 5-year all-cause mortality risk and the absolute risk difference of mortality between patients with heart failure and age-matched and sex-matched heart failure-free controls were assessed using Kaplan–Meier estimates and multivariable Cox regression models. Mortality trends were analysed across five calendar periods (1996–2000, 2001–05, 2006–10, 2011–15, and 2016–20) and three age groups (
ISSN:2666-7568
2666-7568
DOI:10.1016/S2666-7568(24)00029-1