Randomized, crossover trial: comparing the effects of standardized egg‐white meal and Vital® on global gastric emptying parameters and intragastric meal distribution in healthy Asian participants

Background and Aim Measurements of gastric emptying and accommodation for alternative test‐meal protocol during gastric emptying scintigraphy (GES), such as high‐calorie nutrient drinks, are not fully established. We aimed to compare the effects of standardized egg‐white meal (EWM) versus high‐calor...

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Published in:Journal of gastroenterology and hepatology 2024-08, Vol.39 (8), p.1517-1527
Main Authors: Tagiling, Nashrulhaq, Ibrahim, Izleen Laili, Lee, Yeong Yeh, Udin, Muhamad Yusri, Mohamad Kamarulzaman, Mohamad Dzulhilmi, Phoa, Picholas Kian Ann, Damulira, Edrine, Mohd Rohani, Mohd Fazrin, Wan Zainon, Wan Mohd Nazlee, Mat Nawi, Norazlina
Format: Article
Language:English
Subjects:
Adult
Asian People
Beverages
Cross-Over Studies
Egg White
Female
gastric accommodation
Gastric Emptying
Healthy Volunteers
Humans
intragastric meal distribution
Male
Meals
Radionuclide Imaging
reference values
Scintigraphy
Stomach - diagnostic imaging
Stomach - physiology
Young Adult
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Summary:Background and Aim Measurements of gastric emptying and accommodation for alternative test‐meal protocol during gastric emptying scintigraphy (GES), such as high‐calorie nutrient drinks, are not fully established. We aimed to compare the effects of standardized egg‐white meal (EWM) versus high‐calorie nutrient drink (Vital®; Abbott Laboratories) on global GES parameters and intragastric meal distribution at immediate scan (IMD0h). Methods Of 84 screened participants, 60 asymptomatic healthy Asian population (38 females; 24.0 ± 1.5 years; 23.8 ± 2.6 kg/m2) were recruited in this 2 × 2 (AB/BA) crossover trial. Participants were randomized to a 4‐h GES with 99mTc‐radiolabeled EWM (~255.8 kcal), followed by a 200 mL Vital® (300 kcal), or vice versa, separated by a 2‐week washout period. Global meal retention (GMR), power‐exponential model emptying parameters (half‐emptying [T1/2], lag phases [Tlag2%, Tlag5%, Tlag10%]), and IMD0h were determined and compared. Results GMRs for both test meals were within the international standard references for solid GES. Compared to EWM, Vital® exhibited significantly lower GMRs (faster emptying) from 0.5 to 3 h (all P 
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.16585