Myocardial perfusion improvement and mechanism after percutaneous intramyocardial septal radiofrequency ablation in obstructive hypertrophic cardiomyopathy: a study of myocardial contrast echocardiography

• Published in: The international journal of cardiovascular imaging 2024-07, Vol.40 (7), p.1483-1492
• Main Authors: Yao, Lu, Ta, Shengjun, Wang, Jing, Han, Chao, Lei, Changhui, Li, Wenxia, Li, Jing, Wang, Bo, Zhao, Xueli, Liu, Liwen
• Format: Article
• Language: English
• Subjects: Ablation; Blood flow; Blood volume; Cardiac Imaging; Cardiology; Cardiomyopathy; Correlation analysis; Echocardiography; Effectiveness; Heart; Imaging; Medicine; Medicine & Public Health; Microvasculature; Original Paper; Parameters; Perfusion; Radio frequency; Radiofrequency ablation; Radiology; Reperfusion; Septum; Stroke volume; Thickness; Ventricle
• ISSN: 1875-8312; 1569-5794; 1875-8312; 1573-0743
• DOI: 10.1007/s10554-024-03126-7

The data on myocardial perfusion of the percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for obstructive hypertrophic cardiomyopathy (HOCM) are still lacking, although PIMSRA have been proved to be of great safety and efficacy. The aim of this study was to quantitatively analyze the changes in myocardial perfusion after PIMSRA using myocardial contrast echocardiography (MCE). 27 HOCM patients treated with PIMSRA were retrospectively analyzed, and their echocardiographic parameters and perfusion parameters of MCE were collected before and 12 months after PIMSRA. A reperfusion curve was used to quantify microvascular blood volume (A), microvascular flux rate (β), and microvascular blood flow (MBF) of each segment. Then the value difference (Δ) of parameters between post- and pre-operation were calculated. Finally, the correlation between the changes in MBF and in each echocardiographic parameter was analyzed. (1) Compared with baseline, the global A, β and MBF were significantly increased in HOCM patients after PIMSRA (all P