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Unswitched memory B cell deficiency in children with sickle cell disease and response to pneumococcal polysaccharide vaccine

Early mortality in sickle cell disease (SCD) is attributed to increased infections due to loss of splenic function. Marginal zone B cells are important for initial opsonization of pathogens and can be absent in spleen histopathology in SCD. The frequency of unswitched memory B cells (UMBC), the circ...

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Bibliographic Details
Published in:American journal of hematology 2024-06, Vol.99 (6), p.1084-1094
Main Authors: Tubman, Venée N., Maysonet, Daniel, Estrada, Norma, Halder, Tripti, Ramos, Lindsey, Bhamidipati, Sameera, Carisey, Alexandre F., Minard, Charles G., Allen, Carl E.
Format: Article
Language:English
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Summary:Early mortality in sickle cell disease (SCD) is attributed to increased infections due to loss of splenic function. Marginal zone B cells are important for initial opsonization of pathogens and can be absent in spleen histopathology in SCD. The frequency of unswitched memory B cells (UMBC), the circulating correlate of marginal zone B cells, reflects the immunologic function of the spleen. We hypothesized that asplenia in SCD is associated with alterations in the peripheral blood lymphocyte population and explored whether UMBC deficiency was associated with a clinical phenotype. We analyzed B cell subsets and clinical history for 238 children with SCD and 63 controls. The median proportion of UMBCs was lower in children with SCD compared with controls (4.7% vs. 6.6%, p 
ISSN:0361-8609
1096-8652
1096-8652
DOI:10.1002/ajh.27319