Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials

Aims To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany. Methods Clinical parameters were compared between men and women with stages III/IV grades B/C generalized periodontitis at baseline and 1‐year post‐th...

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Published in:Journal of periodontal research 2024-12, Vol.59 (6), p.1175-1183
Main Authors: Castro dos Santos, Nidia, Westphal, Miriam R., Retamal‐Valdes, Belen, Duarte, Poliana Mendes, Figueiredo, Luciene Cristina, Faveri, Marcelo, Shibli, Jamil, Soares, Geisla, Miranda, Tamires, Fermiano, Daiane, Borges, Ivan, Goncalves, Cristiane, Tanaka, Caio Junji, Teles, Flavia, Goodson, Max, Hasturk, Hatice, Van Dyke, Thomas, Ehmke, Benjamin, Eickholz, Peter, Nickles, Katrin, Schlagenhauf, Ulrich, Meyle, Joerg, Kocher, Thomas, Kim, Ti‐Sun, Doyle, Helio, Feres, Magda
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antibiotics
Brazil
Clinical trials
Dental Scaling
Female
Gender
Gum disease
Humans
Male
Middle Aged
Patients
periodontal attachment loss
Periodontal Attachment Loss - therapy
Periodontal Pocket - therapy
Periodontitis
Periodontitis - therapy
Randomized Controlled Trials as Topic
Retrospective Studies
retrospective study
Root Planing
sex
Sex Factors
therapy
Treatment Outcome
United States
Women
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Summary:Aims To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany. Methods Clinical parameters were compared between men and women with stages III/IV grades B/C generalized periodontitis at baseline and 1‐year post‐therapy, including scaling and root planing with or without antibiotics. Results Data from 1042 patients were analyzed. Men presented a tendency towards higher probing depth (p = .07, effect size = 0.11) and clinical attachment level (CAL) than women at baseline (p = .01, effect size = 0.16). Males also presented statistically significantly lower CAL gain at sites with CAL of 4–6 mm at 1‐year post‐therapy (p = .001, effect size = 0.20). Among patients with Grade B periodontitis who took antibiotics, a higher frequency of women achieved the endpoint for treatment (i.e., ≤4 sites PD ≥5 mm) at 1 year than men (p 
ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.13272