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Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases
Background Thyroid hormones are primarily responsible for the brain development in perinatal mammals. However, this process can be inhibited by external factors such as environmental chemicals. Perinatal mammals are viviparous, which makes direct fetal examination difficult. Methods We used metamorp...
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| Published in: | Molecular biology reports 2024-12, Vol.51 (1), p.624-624, Article 624 |
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| creator | Ishihara, Akinori |
| description | Background
Thyroid hormones are primarily responsible for the brain development in perinatal mammals. However, this process can be inhibited by external factors such as environmental chemicals. Perinatal mammals are viviparous, which makes direct fetal examination difficult.
Methods
We used metamorphic amphibians, which exhibit many similarities to perinatal mammals, as an experimental system. Therefore, using metamorphic amphibians, we characterized the gene expression of matrix metalloproteinases, which play an important role in brain development.
Results
The expression of many matrix metalloproteinases (
mmps
) was characteristically induced during metamorphosis. We also found that the expression of many
mmps
was induced by T
3
and markedly inhibited by hydroxylated polychlorinated biphenyls (PCBs).
Conclusion
Overall, our findings suggest that hydroxylated PCBs disrupt normal brain development by disturbing the gene expression of
mmps
. |
| doi_str_mv | 10.1007/s11033-024-09555-w |
| format | article |
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Thyroid hormones are primarily responsible for the brain development in perinatal mammals. However, this process can be inhibited by external factors such as environmental chemicals. Perinatal mammals are viviparous, which makes direct fetal examination difficult.
Methods
We used metamorphic amphibians, which exhibit many similarities to perinatal mammals, as an experimental system. Therefore, using metamorphic amphibians, we characterized the gene expression of matrix metalloproteinases, which play an important role in brain development.
Results
The expression of many matrix metalloproteinases (
mmps
) was characteristically induced during metamorphosis. We also found that the expression of many
mmps
was induced by T
3
and markedly inhibited by hydroxylated polychlorinated biphenyls (PCBs).
Conclusion
Overall, our findings suggest that hydroxylated PCBs disrupt normal brain development by disturbing the gene expression of
mmps
.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-024-09555-w</identifier><identifier>PMID: 38710963</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Animals ; Biomedical and Life Sciences ; Brain ; Brain - drug effects ; Brain - growth & development ; Brain - metabolism ; Brief Report ; Cell cycle ; Fetuses ; Frogs ; Gene expression ; Gene Expression Regulation, Developmental - drug effects ; Histology ; Hormones ; Hydroxylation ; Life Sciences ; Matrix metalloproteinase ; Matrix Metalloproteinases - genetics ; Matrix Metalloproteinases - metabolism ; Metamorphosis ; Metamorphosis, Biological - drug effects ; Metamorphosis, Biological - genetics ; Molecular biology ; Morphology ; PCB ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - toxicity ; Polymerase chain reaction ; Reptiles & amphibians ; Thyroid gland ; Thyroid hormones ; Thyroid Hormones - metabolism ; Triiodothyronine ; Variance analysis ; Xenopus laevis - genetics ; Xenopus laevis - metabolism</subject><ispartof>Molecular biology reports, 2024-12, Vol.51 (1), p.624-624, Article 624</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-d4e036b058d8fa532b6938e5028f4d34665783b9d322cb442e3ac9104bcaf4613</cites><orcidid>0000-0002-4513-2424</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38710963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishihara, Akinori</creatorcontrib><title>Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Background
Thyroid hormones are primarily responsible for the brain development in perinatal mammals. However, this process can be inhibited by external factors such as environmental chemicals. Perinatal mammals are viviparous, which makes direct fetal examination difficult.
Methods
We used metamorphic amphibians, which exhibit many similarities to perinatal mammals, as an experimental system. Therefore, using metamorphic amphibians, we characterized the gene expression of matrix metalloproteinases, which play an important role in brain development.
Results
The expression of many matrix metalloproteinases (
mmps
) was characteristically induced during metamorphosis. We also found that the expression of many
mmps
was induced by T
3
and markedly inhibited by hydroxylated polychlorinated biphenyls (PCBs).
Conclusion
Overall, our findings suggest that hydroxylated PCBs disrupt normal brain development by disturbing the gene expression of
mmps
.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brief Report</subject><subject>Cell cycle</subject><subject>Fetuses</subject><subject>Frogs</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Histology</subject><subject>Hormones</subject><subject>Hydroxylation</subject><subject>Life Sciences</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinases - genetics</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Metamorphosis</subject><subject>Metamorphosis, Biological - drug effects</subject><subject>Metamorphosis, Biological - genetics</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>PCB</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Polymerase chain reaction</subject><subject>Reptiles & amphibians</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - metabolism</subject><subject>Triiodothyronine</subject><subject>Variance analysis</subject><subject>Xenopus laevis - genetics</subject><subject>Xenopus laevis - metabolism</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQhy0EotvCC3BAlrhwCYxjO3-OqCq0UiUuIHGLnHjCunLsYDvt5u14NJzdAhIHDpbl0TffjPwj5BWDdwygfh8ZA84LKEUBrZSyeHhCdkzWvBBt3TwlO-DACtFIdkbOY7wDAMFq-Zyc8aZm0FZ8R35erzr4w2pVQk1nb9dhb30w7vjuzbxHt9pIJ7VSNY44JJr2mM8avNF078PkHRbG6WXYGoIyjmq8R-vnCV2iesmy73TCpCYf5r2PJlI_0m_o_LxEahXe50q_Um1iWkK_0dsIPMwBYzTebfikUjCHo8ZmdfAJ844R4wvybFQ24svH-4J8_Xj15fK6uP386ebyw20x8LJKhRYIvOpBNroZleRlX7W8QQllMwrNRVXJuuF9q3lZDr0QJXI1tAxEP6hRVIxfkLcnb579Y8GYusnEAa1VDv0SOw6SZSOAzOibf9A7vwSXtztSJZe85pkqT9QQfIwBx24OZlJh7Rh0W77dKd8u59sd8-0ectPrR_XST6j_tPwONAP8BMR5-3cMf2f_R_sLvyi3LQ</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Ishihara, Akinori</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4513-2424</orcidid></search><sort><creationdate>20241201</creationdate><title>Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases</title><author>Ishihara, Akinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-d4e036b058d8fa532b6938e5028f4d34665783b9d322cb442e3ac9104bcaf4613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brief Report</topic><topic>Cell cycle</topic><topic>Fetuses</topic><topic>Frogs</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Histology</topic><topic>Hormones</topic><topic>Hydroxylation</topic><topic>Life Sciences</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinases - genetics</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Metamorphosis</topic><topic>Metamorphosis, Biological - drug effects</topic><topic>Metamorphosis, Biological - genetics</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>PCB</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Polymerase chain reaction</topic><topic>Reptiles & amphibians</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - metabolism</topic><topic>Triiodothyronine</topic><topic>Variance analysis</topic><topic>Xenopus laevis - genetics</topic><topic>Xenopus laevis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishihara, Akinori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishihara, Akinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>51</volume><issue>1</issue><spage>624</spage><epage>624</epage><pages>624-624</pages><artnum>624</artnum><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Background
Thyroid hormones are primarily responsible for the brain development in perinatal mammals. However, this process can be inhibited by external factors such as environmental chemicals. Perinatal mammals are viviparous, which makes direct fetal examination difficult.
Methods
We used metamorphic amphibians, which exhibit many similarities to perinatal mammals, as an experimental system. Therefore, using metamorphic amphibians, we characterized the gene expression of matrix metalloproteinases, which play an important role in brain development.
Results
The expression of many matrix metalloproteinases (
mmps
) was characteristically induced during metamorphosis. We also found that the expression of many
mmps
was induced by T
3
and markedly inhibited by hydroxylated polychlorinated biphenyls (PCBs).
Conclusion
Overall, our findings suggest that hydroxylated PCBs disrupt normal brain development by disturbing the gene expression of
mmps
.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38710963</pmid><doi>10.1007/s11033-024-09555-w</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4513-2424</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Brain Brain - drug effects Brain - growth & development Brain - metabolism Brief Report Cell cycle Fetuses Frogs Gene expression Gene Expression Regulation, Developmental - drug effects Histology Hormones Hydroxylation Life Sciences Matrix metalloproteinase Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Metamorphosis Metamorphosis, Biological - drug effects Metamorphosis, Biological - genetics Molecular biology Morphology PCB Polychlorinated biphenyls Polychlorinated Biphenyls - toxicity Polymerase chain reaction Reptiles & amphibians Thyroid gland Thyroid hormones Thyroid Hormones - metabolism Triiodothyronine Variance analysis Xenopus laevis - genetics Xenopus laevis - metabolism |
| title | Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases |
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