Poor Bone Mineral Density Is Associated With Increased Risk of Urological Bone Metastases

• Published in: Urology (Ridgewood, N.J.) N.J.), 2024-10, Vol.192, p.88-96
• Main Authors: Bowling, Gartrell C., Alex Albright, James, Maloney, Trevor J., Quinn, Matthew S., Daniels, Alan H., Chesnut, Gregory T.
• Format: Article
• Language: English
• ISSN: 0090-4295; 1527-9995; 1527-9995
• DOI: 10.1016/j.urology.2024.04.043

To investigate whether a diagnosis of precancer poor bone mineral density (PBMD) is associated with higher risk of urological cancer bone metastasis. The PearlDiver Database was utilized to conduct a retrospective, propensity-matched cohort analysis of adult patients diagnosed with kidney, bladder, prostate, and testicular cancer with and without a prior diagnosis of PBMD, defined as osteopenia or osteoporosis. Unadjusted and adjusted odds ratios (OR) and 95% confidence intervals are used to compare the rate of newly diagnosed bone metastases between 6months and 3years of the initial cancer diagnosis between the experimental and control cohorts. Among 685,066 patients with urological cancers, precancer PBMD was associated with increased odds of bone metastasis at various time periods (1week, 6months, 1, 2, and 3years). The strongest association was appreciated within 1week of cancer diagnosis (kidney: adjusted odds ratio [aOR], 2.37, P