Sprayable and self-healing chitosan-based hydrogels for promoting healing of infected wound via anti-bacteria, anti-inflammation and angiogenesis

Treatment of infected wound by simultaneously eliminating bacteria and inducing angiogenesis to promote wound tissue regeneration remains a clinical challenge. Dynamic and reversable hydrogels can adapt to irregular wound beds, which have raised great attention as wound dressings. Herein, a sprayabl...

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Bibliographic Details
Published in:Carbohydrate polymers 2024-08, Vol.337, p.122147, Article 122147
Main Authors: Tan, Yujiao, Xu, Changliang, Liu, Ying, Bai, Yun, Li, Xiaoyun, Wang, Xiaoying
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antibacterial
Bandages
Chitosan
Chitosan - chemistry
Chitosan - pharmacology
Dextrans - chemistry
Dextrans - pharmacology
Humans
Hydrogels - chemistry
Hydrogels - pharmacology
Insulin-Like Growth Factor I
Male
Mice
Neovascularization, Physiologic - drug effects
pH-responsive
Sprayable hydrogels
Staphylococcus aureus - drug effects
Wound dressing
Wound Healing - drug effects
Wound Infection - drug therapy
Wound Infection - microbiology
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Summary:Treatment of infected wound by simultaneously eliminating bacteria and inducing angiogenesis to promote wound tissue regeneration remains a clinical challenge. Dynamic and reversable hydrogels can adapt to irregular wound beds, which have raised great attention as wound dressings. Herein, a sprayable chitosan-based hydrogel (HPC/CCS/ODex-IGF1) was developed using hydroxypropyl chitosan (HPC), caffeic acid functionalized chitosan (CCS), oxidized dextran (ODex) to crosslink through the dynamic imine bond, which was pH-responsive to the acidic microenvironment and could controllably release insulin growth factor-1 (IGF1). The HPC/CCS/ODex-IGF1 hydrogels not only showed self-healing, self-adaptable and sprayable properties, but also exhibited excellent antibacterial ability, antioxidant property, low-cytotoxicity and angiogenetic activity. In vivo experiments demonstrated that hydrogels promoted tissue regeneration and healing of bacteria-infected wound with a rate of approximately 98.4 % on day 11 by eliminating bacteria, reducing inflammatory and facilitating angiogenesis, demonstrating its great potential for wound dressing. [Display omitted]
ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2024.122147