Improvement of anti-prion efficacy with stearoxy conjugation of hydroxypropyl methylcellulose in prion-infected mice

Prion diseases are fatal transmissible neurodegenerative disorders. Among known anti-prions, hydroxypropyl methylcellulose compounds (HPMCs) are unique in their chemical structure and action. They have several excellent anti-prion properties but the effectiveness depends on the prion-infected mouse...

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Bibliographic Details
Published in:Carbohydrate polymers 2024-08, Vol.337, p.122163-122163, Article 122163
Main Authors: Teruya, Kenta, Oguma, Ayumi, Iwabuchi, Sara, Nishizawa, Keiko, Doh-ura, Katsumi
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Hydroxypropyl methylcellulose
Hypromellose Derivatives - chemistry
Mice
Prion disease
Prion Diseases - drug therapy
Prophylaxis
Stearoxy ester
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Summary:Prion diseases are fatal transmissible neurodegenerative disorders. Among known anti-prions, hydroxypropyl methylcellulose compounds (HPMCs) are unique in their chemical structure and action. They have several excellent anti-prion properties but the effectiveness depends on the prion-infected mouse model. In the present study, we investigated the effects of stearoxy-modified HPMCs on prion-infected cells and mice. Stearoxy modification improved the anti-prion efficacy of HPMCs in prion-infected cells and significantly prolonged the incubation period in a lower HPMC-responding mouse model. However, stearoxy modification showed no improvement over nonmodified HPMCs in an HPMC-responding mouse model. These results offer a new line of inquiry for use with prion-infected mice that do not respond well to HPMCs. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2024.122163