Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury

Ischemic stroke presents a global health challenge, necessitating an in-depth comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy salvages brain tissue, it also triggers detrimental cerebral ischemia-reperfusion injury (CIRI). In our investigation, we observed...

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Bibliographic Details
Published in:Neurochemical research 2024-07, Vol.49 (7), p.1806-1822
Main Authors: Zhao, Lan, Li, Yanan, Wang, Wei, Qi, Xue, Wang, Su, Song, Wenqin, Li, Ting, Gao, Wenwei
Format: Article
Language:English
Subjects:
Autophagy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell death
Chelating agents
Damage
Deferoxamine
Ferrous ions
Global health
Glucose
Hypoxia
Injuries
Iron
Ischemia
Molecular modelling
Neurochemistry
Neurology
Neurosciences
Original Paper
Oxidative stress
Oxygen
Public health
Reperfusion
Stimulators
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Summary:Ischemic stroke presents a global health challenge, necessitating an in-depth comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy salvages brain tissue, it also triggers detrimental cerebral ischemia-reperfusion injury (CIRI). In our investigation, we observed the activation of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in an oxygen-glucose deprivation/reoxygenation (OGD/R) model using HT22 cells ( P  
ISSN:0364-3190
1573-6903
1573-6903
DOI:10.1007/s11064-024-04146-4