Chemoenzymatic formal synthesis of (+)-brazilin

Herein, the manuscript presents a chemoenzymatic formal synthetic route of (+)-brazilin, a homoisoflavonoid natural product with a chroman skeleton cis-fused with a 2,3-dihydro-1 -indene unit, which is isolated from the traditional Chinese medicine, . The key feature of the synthetic strategy includ...

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Published in:Natural product research 2024-05, p.1-11
Main Authors: Liu, Jiangtao, Han, Xue, Yu, Liuping, Zhang, Jiandong, Huang, Shuangping, Yang, Xihua, Chang, Honghong
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creator Liu, Jiangtao
Han, Xue
Yu, Liuping
Zhang, Jiandong
Huang, Shuangping
Yang, Xihua
Chang, Honghong
description Herein, the manuscript presents a chemoenzymatic formal synthetic route of (+)-brazilin, a homoisoflavonoid natural product with a chroman skeleton cis-fused with a 2,3-dihydro-1 -indene unit, which is isolated from the traditional Chinese medicine, . The key feature of the synthetic strategy includes an enzyme-mediated desymmetrization by employing lipase from type B (CALB) and a one-pot S 2/hydrolysis reaction.
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title Chemoenzymatic formal synthesis of (+)-brazilin
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