Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

• Published in: Multiple sclerosis 2024-08, Vol.30 (9), p.1176-1184
• Main Authors: Andersen, Mette Louise, Jølving, Line Riis, Iachina, Maria, Stenager, Egon, Knudsen, Torben, Nørgård, Bente Mertz
• Format: Article
• Language: English
• Subjects: Adult; Antibiotics; Child, Preschool; Children; Denmark - epidemiology; Female; Gestational age; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Infections; Infections - epidemiology; Male; Morbidity; Mothers; Multiple sclerosis; Multiple Sclerosis - epidemiology; Pregnancy; Premature birth; Premature Birth - epidemiology; Registries; Regression analysis; Risk Factors; Small for gestational age
• ISSN: 1352-4585; 1477-0970; 1477-0970
• DOI: 10.1177/13524585241249077

Background: Mothers with multiple sclerosis are at increased risk of preterm birth and small for gestational age infants. Both conditions pose a risk of morbidity, including early-life infections. Objective: This study aimed to assess the risk of infections in the first 3 years of life among children born preterm or small for gestational age to mothers with multiple sclerosis. Methods: We used Danish national health registers to establish the study cohort of all births by women with MS born from 1995 to 2023. In Cox regression models, we estimated hazard ratios (HRs) of infections in preterm or small for gestational age children. Results: Preterm children had an adjusted HR of 1.49 (95% confidence interval (95% CI) 1.15–1.93) for hospital-diagnosed infection and 0.88 (95% CI 0.72–1.06) for antibiotic prescriptions. Small for gestational age children had an adjusted HR of 0.81 (95% CI 0.54–1.22) for hospital-diagnosed infection and 1.07 (95% CI 0.82–1.38) for antibiotic prescriptions. Conclusion: Children born preterm to mothers with multiple sclerosis had an increased risk of hospital-diagnosed infections in the first 3 years of life, but not of mild-to-moderate infections evaluated on prescriptions. Children born small for gestational age did not have an increased risk of infections.