Regulation of Oxidative Stress and Apoptosis in Streptozotocin‐Induced Diabetic Rats by Egyptian Sidr Honey

Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over time to severe damage to numerous tissues. The present study aimed to estimate the effect of Egyptian Sidr honey against streptozotocin (STZ)‐induced diabetes in rats. Diabetic rats were treated with Sidr hone...

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Published in:Chemistry & biodiversity 2024-07, Vol.21 (7), p.e202400351-n/a
Main Authors: El‐Aarag, Bishoy, Shehata, Sahar Bahgat, El‐Garawani, Islam M., El‐Seedi, Hesham R., Nofal, Amany Ebrahim
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
BAX protein
Bcl-2 protein
Blood
Blood levels
Caspase
Diabetes
Diabetes mellitus
Enzymes
Global health
Honey
Hyperglycemia
Malondialdehyde
Metformin
Nitric oxide
Oxidative stress
Public health
Sidr honey
Streptozocin
Streptozotocin
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Summary:Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over time to severe damage to numerous tissues. The present study aimed to estimate the effect of Egyptian Sidr honey against streptozotocin (STZ)‐induced diabetes in rats. Diabetic rats were treated with Sidr honey daily for 4 consecutive weeks. The biochemical profile of blood samples was measured. Furthermore, the activity of antioxidant enzymes, nitric oxide (NO), and malonaldehyde (MDA) were examined in hepatic and pancreatic tissues. Moreover, the expression of Bax, Caspase‐3, and Bcl2 proteins were measured. Results revealed that the capability of Sidr honey to decline the elevated blood glucose and fructosamine levels. Also, the honey decreased the levels of NO and MDA. Furthermore, it regulated the antioxidant enzymes activity. Moreover, it reduced the expression levels of Caspase‐3 and Bax while increased the Bcl2 level. In conclusion, Sidr honey can regulate hyperglycemia, oxidative stress, apoptosis, and antioxidant enzymes in STZ‐induced diabetic rats.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400351