Honokiol and magnolol: A review of structure-activity relationships of their derivatives

Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neoligna...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2024-07, Vol.223, p.114132-114132, Article 114132
Main Authors: Dai, Si-Yang, Qin, Wen-Xiu, Yu, Shuo, Li, Chang, Yang, Yi-Hui, Pei, Yue-Hu
Format: Article
Language:English
Subjects:
Allyl Compounds
Anti-tumor
Biphenyl Compounds - antagonists & inhibitors
Biphenyl Compounds - chemistry
Biphenyl Compounds - pharmacology
Honokiol
Humans
Lignans - chemistry
Lignans - pharmacology
Magnolol
Metabolism
Molecular Structure
Neuroprotection
Phenols
Structure-Activity Relationship
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Summary:Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neolignan drugs. This review focuses on recent advances in the medicinal chemistry of HK and MAG derivatives, especially their structure-activity relationships. In addition, it also presents a comprehensive summary of the pharmacology, biosynthetic pathways, and metabolic characteristics of HK and MAG. This review can provide pharmaceutical chemists deeper insights into medicinal research on HK and MAG, and a reference for the rational design of HK and MAG derivatives. This review presents a comprehensive summarization of the pharmacology, biosynthetic pathways, metabolic characteristics, and chemical structure modification of honokiol and magnolol, especially focusing on the derivatives' structure-activity relationships. [Display omitted] •Honokiol and magnolol possess a broad range of biological activities.•This review mainly summarized structure–activity relationships of their derivatives.•It also involves the pharmacology, biosynthetic pathways and metabolites of honokiol.•It provides some ideas for further research on honokiol and magnolol derivatives.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2024.114132