Emotional Stress Induces Adaptive Response in Rat Lymphocytes to Subsequent Ionizing Radiation Exposure

We studied the molecular mechanisms of cross-adaptation to ionizing radiation (1 Gy) of lymphocytes isolated from rats subjected to emotional stress. The effects of chronic (CES; various types of stress exposure) and acute (AES; forced swimming) emotional stress in rats on indicators of oxidative st...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-03, Vol.176 (5), p.548-554
Main Authors: Umryukhin, P. E., Mikheeva, E. N., Mishina, U. M., Proskurnina, E. V., Malinovskaya, E. M., Martynov, A. V., Ershova, E. S., Veiko, N. N., Kostyuk, S. V.
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Physiological - radiation effects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell death
DNA damage
DNA Damage - radiation effects
Emotions
Flow cytometry
Influence
Internal Medicine
Ionizing radiation
Laboratory Medicine
Lymphocytes
Lymphocytes - metabolism
Lymphocytes - radiation effects
Male
Molecular modelling
NADPH Oxidase 4 - genetics
NADPH Oxidase 4 - metabolism
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
NOX4 protein
Oxidation
Oxidative stress
Oxidative Stress - radiation effects
Pathology
Proteins
Radiation
Radiation, Ionizing
Rats
Rats, Wistar
Reagents
Stress, Psychological - metabolism
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Summary:We studied the molecular mechanisms of cross-adaptation to ionizing radiation (1 Gy) of lymphocytes isolated from rats subjected to emotional stress. The effects of chronic (CES; various types of stress exposure) and acute (AES; forced swimming) emotional stress in rats on indicators of oxidative stress, cell death, and levels of NRF2 and NOX4 proteins involved in the development of the adaptive response were analyzed in isolated lymphocytes. It was found that stress induced an adaptive response in rat lymphocytes and triggered processes similar to the adaptive response induced by low doses of ionizing radiation: an increase in the level of oxidized DNA and cell death, as well as an increase in the content of NOX4 and NRF2 proteins. In animals subjected to emotional stress, suppressed DNA oxidation in response to irradiation, reduced levels of protective factor NRF2, as well as lymphocyte death were observed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-024-06065-4