The metabolic fuel of paroxysmal nocturnal haemoglobinuria

Metabolic reprogramming has been investigated in haematological malignancies. To date, a few studies have analysed the metabolic profile of paroxysmal nocturnal haemoglobinuria (PNH). The study by Chen and colleagues sheds light on the involvement of metabolic changes in the proliferation of PNH clo...

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Bibliographic Details
Published in:British journal of haematology 2024-06, Vol.204 (6), p.2162-2164
Main Authors: Guarnera, Luca, Visconte, Valeria
Format: Article
Language:English
Subjects:
Hemoglobinuria, Paroxysmal - metabolism
Histones
Humans
Jumonji Domain-Containing Histone Demethylases - genetics
Jumonji Domain-Containing Histone Demethylases - metabolism
Malignancy
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Summary:Metabolic reprogramming has been investigated in haematological malignancies. To date, a few studies have analysed the metabolic profile of paroxysmal nocturnal haemoglobinuria (PNH). The study by Chen and colleagues sheds light on the involvement of metabolic changes in the proliferation of PNH clones. Commentary on: Chen et al. The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of PNH clones through cell metabolic reprogramming. Br J Haematol 2024;204:2468-2479.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.19510