Electrospun medicated gelatin/polycaprolactone Janus fibers for photothermal-chem combined therapy of liver cancer

• Published in: International journal of biological macromolecules 2024-06, Vol.269, p.132113-132113, Article 132113
• Main Authors: Zhou, Jianfeng, Chen, Yaoning, Liu, Yang, Huang, Tianyue, Xing, Jia, Ge, Ruiliang, Yu, Deng-Guang
• Format: Article
• Language: English
• Subjects: 808 nm near-infrared laser; Combination therapy; Dihydromyricetin; Electrospinning; Janus membranes; Liver cancer; Photothermic agent
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.132113

Liver cancer is a common cancer in the world, and core-shell nanoparticles as a commonly used combination therapy for local tumor ablation, have many shortcomings. In this study, photothermal Janus nanofibers were prepared using a electrospinning technology for tumor treatment, and the products were characterized and in vitro photothermal performance investigated. The micromorphology analysis showed that the photothermic agent CuS and electrospun fibers (loaded with CuS and anticancer drug dihydromyricetin) were successfully prepared, with diameters of 11.58 ± 0.27 μm and 1.19 ± 0.01 μm, respectively. Water contact angle and tensile test indicated that the fiber membranes has a certain hydrophilic adhesion and excellent mechanical strength. The fiber membranes has 808 nm near-infrared laser photothermal heating performance and photothermal stability, and it also has a strong response to the laser that penetrates biological tissue. In addition, in vitro cell culture and in vivo implantation study showed that the fiber membranes could kill HepG2 hepatocellular carcinoma cells combined with photothermal-chem and could be enriched in the implantation area, respectively. Hence, the Janus membranes may be a potential cancer treatment material. [Display omitted] •Gelatin combined with PCL was used as a photothermal-chem component carrier material•Through a special spinneret, eccentric 2-fluid electrospinning was conducted and photothermal-chem Janus fiber was obtained•CuS and dihydromyricetin were used to prepare functional materials for combined photothermal-chem therapy of liver cancer•Photothermal fiber has excellent photothermal performance and photothermal stability•Photothermal fiber temperature can respond to the apoptotic value of tumor cells