Shedding light on vitamin D in tuberculosis: A comprehensive review of clinical trials and discrepancies

Over the past few decades, there has been extensive research on the use of vitamin D as an adjunctive therapy in the treatment and prevention of tuberculosis. In vitro studies have provided valuable insights into the mechanisms by which vitamin D activates the immune response to combat Mycobacterium...

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Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2024-06, Vol.85, p.102300-102300, Article 102300
Main Authors: Santos-Mena, Alan, González-Muñiz, Oscar E., Jacobo-Delgado, Yolanda M., Rivas-Santiago, Bruno
Format: Article
Language:English
Subjects:
Adjuvant
Animals
Antitubercular Agents - administration & dosage
Antitubercular Agents - therapeutic use
Clinical investigation
Clinical Trials as Topic
Humans
Mycobacterium tuberculosis - drug effects
Treatment
Tuberculosis
Tuberculosis - drug therapy
Vitamin D
Vitamin D - administration & dosage
Vitamin D - therapeutic use
Vitamins - administration & dosage
Vitamins - therapeutic use
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Summary:Over the past few decades, there has been extensive research on the use of vitamin D as an adjunctive therapy in the treatment and prevention of tuberculosis. In vitro studies have provided valuable insights into the mechanisms by which vitamin D activates the immune response to combat Mycobacterium tuberculosis. These encouraging findings have spurred clinical investigations globally to assess the effectiveness of vitamin D as a preventive measure and as an adjunctive treatment for tuberculosis. However, the results from these clinical studies have been contradictory, with some demonstrating clear efficacy while others report only modest or no activity. In this review, we aim to analyze the clinical studies on vitamin D and examine the possible discrepancies observed in their outcomes.
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2024.102300