Urinary Ferritin as a Noninvasive Means of Assessing Iron Status in Young Children

Iron deficiency (ID) is the most common nutritional deficiency affecting young children. Serum ferritin concentration is the preferred biomarker for measuring iron status because it reflects iron stores; however, blood collection can be distressing for young children and can be logistically difficul...

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Bibliographic Details
Published in:The Journal of nutrition 2024-09, Vol.154 (9), p.2688-2695
Main Authors: Moumin, Najma A, D’Vaz, Nina, Kidd, Courtney, MacRae, Andrea, Zhou, Shao J, Richards, Toby, Palmer, Debra J, Grzeskowiak, Luke E, Sullivan, Thomas R, Green, Tim J
Format: Article
Language:English
Subjects:
Australia
Biomarkers
Blood levels
Children
Childrens health
Confidence intervals
Correlation
Creatinine
Ferritin
Iron
Iron deficiency
iron status
noninvasive biomarker
Nutrient deficiency
Performance prediction
serum ferritin
Specific gravity
the ORIGINS project
Urinalysis
urinary ferritin
Urine
young children
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Summary:Iron deficiency (ID) is the most common nutritional deficiency affecting young children. Serum ferritin concentration is the preferred biomarker for measuring iron status because it reflects iron stores; however, blood collection can be distressing for young children and can be logistically difficult. A noninvasive means to measure iron status would be attractive to either diagnose or screen for ID in young children. This study aimed to determine the correlation between urinary and serum ferritin concentrations in young children; to determine whether correcting urinary ferritin for creatinine and specific gravity improves the correlation; and to determine a urine ferritin cut point to predict ID. Validation study was conducted using paired serum and urine collected from 3-y-old children (n = 142) participating in a longitudinal birth cohort study: the ORIGINS project in Perth, Western Australia. We calculated the sensitivity, specificity, positive, and negative predictive values of urinary ferritin amount in identifying those with ID at the clinical cut point used by the World Health Organization (serum ferritin concentration of
ISSN:0022-3166
1541-6100
1541-6100
DOI:10.1016/j.tjnut.2024.04.040