An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing

• Published in: ACS applied materials & interfaces 2024-05, Vol.16 (20), p.25799-25812
• Main Authors: Guo, Fanyi, Li, Jianfeng, Chen, Ziyu, Wang, Tianxiao, Wang, Ruyu, Wang, Tianyao, Bian, Yifeng, Du, Yifei, Yuan, Hua, Pan, Yongchu, Jin, Jianliang, Jiang, Huijun, Han, Feng, Jiang, Jiandong, Wu, Fan, Wang, Yuli
• Format: Article
• Language: English
• Subjects: Animals; Biological and Medical Applications of Materials and Interfaces; Bone Regeneration - drug effects; Hydrogels - chemistry; Hydrogels - pharmacology; Male; Neovascularization, Physiologic - drug effects; Osteogenesis - drug effects; Phosphorus - chemistry; Rats; Reactive Oxygen Species - metabolism; Tooth Extraction; Tooth Socket - drug effects; Wound Healing - drug effects
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.4c03278

The excess production of reactive oxygen species (ROS) will delay tooth extraction socket (TES) healing. In this study, we developed an injectable thermosensitive hydrogel (NBP@BP@CS) used to treat TES healing. The hydrogel formulation incorporated black phosphorus (BP) nanoflakes, recognized for their accelerated alveolar bone regeneration and ROS-scavenging properties, and dl-3-n-butylphthalide (NBP), a vasodilator aimed at enhancing angiogenesis. In vivo investigations strongly demonstrated that NBP@BP@CS improved TES healing due to antioxidation and promotion of alveolar bone regeneration by BP nanoflakes. The sustained release of NBP from the hydrogel promoted neovascularization and vascular remodeling. Our results demonstrated that the designed thermosensitive hydrogel provided great opportunity not only for ROS elimination but also for the promotion of osteogenesis and angiogenesis, reflecting the “three birds with one stone” concept, and has tremendous potential for rapid TES healing.