Deregulation of New Cell Death Mechanisms in Leukemia

Hematological malignancies are among the top five most frequent forms of cancer in developed countries worldwide. Although the new therapeutic approaches have improved the quality and the life expectancy of patients, the high rate of recurrence and drug resistance are the main issues for counteracti...

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Bibliographic Details
Published in:Cancers 2024-05, Vol.16 (9), p.1657
Main Authors: Favale, Gregorio, Donnarumma, Federica, Capone, Vincenza, Della Torre, Laura, Beato, Antonio, Carannante, Daniela, Verrilli, Giulia, Nawaz, Asmat, Grimaldi, Francesco, De Simone, Maria Carla, Del Gaudio, Nunzio, Megchelenbrink, Wouter Leonard, Caraglia, Michele, Benedetti, Rosaria, Altucci, Lucia, Carafa, Vincenzo
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
B cells
Biochemistry
Cancer
Cancer therapies
Cell activation
Cell death
Chemotherapy
Cloning
Development and progression
Drug resistance
Ferroptosis
Health aspects
Homeostasis
Immunotherapy
Kinases
Leukemia
Life span
Lymphoma
Malignancy
Metastasis
Molecular modelling
Morphology
Mutation
Oncology, Experimental
Physiology
Stem cells
Tumors
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Summary:Hematological malignancies are among the top five most frequent forms of cancer in developed countries worldwide. Although the new therapeutic approaches have improved the quality and the life expectancy of patients, the high rate of recurrence and drug resistance are the main issues for counteracting blood disorders. Chemotherapy-resistant leukemic clones activate molecular processes for biological survival, preventing the activation of regulated cell death pathways, leading to cancer progression. In the past decade, leukemia research has predominantly centered around modulating the well-established processes of apoptosis (type I cell death) and autophagy (type II cell death). However, the development of therapy resistance and the adaptive nature of leukemic clones have rendered targeting these cell death pathways ineffective. The identification of novel cell death mechanisms, as categorized by the Nomenclature Committee on Cell Death (NCCD), has provided researchers with new tools to overcome survival mechanisms and activate alternative molecular pathways. This review aims to synthesize information on these recently discovered RCD mechanisms in the major types of leukemia, providing researchers with a comprehensive overview of cell death and its modulation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16091657