The Role of Surgery in Pleural Mesothelioma

Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides...

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Bibliographic Details
Published in:Cancers 2024-05, Vol.16 (9), p.1719
Main Authors: Lapidot, Moshe, Sattler, Martin
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Cancer therapies
Chemotherapy
Cohort analysis
Development and progression
Diagnosis
Health aspects
Histology
Immunotherapy
Lymphatic system
Mesothelioma
Morbidity
Mortality
Oncology
Ostomy
Palliative care
Patients
Pemetrexed
Prognosis
Surgeons
Surgery
Survival
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Summary:Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the use of chemotherapy, immunotherapy, or multimodality treatment. The goal of surgery as part of multimodality treatment is to accomplish macroscopic complete resection with the eradication of grossly visible and palpable disease. Over the past two decades, many medical centers worldwide have shifted from performing extra-pleural pneumonectomy (EPP) to pleurectomy decortication (PD). This transition is motivated by the lower rates of short-term mortality and morbidity associated with PD and similar or even better long-term survival outcomes, compared to EPP. This review aims to outline the role of surgery in diagnosing, staging, and treating patients with pleural mesothelioma.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16091719