Epoxy resin bioactive dental implant capped with hydroxyapatite and curcumin nanoparticles: a novel approach

Objective In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs). Materials and methods The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility stud...

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Published in:Oral and maxillofacial surgery 2024-09, Vol.28 (3), p.1303-1312
Main Author: Senthil, Rethinam
Format: Article
Language:English
Subjects:
Antimicrobial agents
Biocompatibility
Biocompatible Materials - chemistry
Curcumin - chemistry
Curcumin - pharmacology
Dental Implants
Durapatite - chemistry
Epoxy resins
Epoxy Resins - chemistry
Humans
Hydroxyapatite
Materials Testing
Medicine
Medicine & Public Health
Microscopy, Electron, Scanning
Nanoparticles
Oral and Maxillofacial Surgery
Osteoblasts - drug effects
Tensile Strength
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Summary:Objective In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs). Materials and methods The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility study. The scanning electron microscopy (SEM) morphology of the BDI was observed HA mineralized crystal layer after being immersed in the stimulated body fluids (SBF) solution. Results The mechanical properties of the BDI exhibited tensile strength (250.61  ±  0.43 MPa), elongation at break (215.66  ±  0.87%), flexural modulus (03.90  ±  0.12 GPa), water absorption (05.68  ±  0.15%), and water desorption (06.42  ±  0.14%). The antimicrobial activity of BDI was observed in excellent zone of inhibition against the gram-negative (15.33  ±  0.04%) and gram- positive (15.98  ±  0.07%) bacteria. The biocompatibility study of BDI on osteoblasts cell line (MG-63) was analyzed using MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results were observed 85% viable cells present in the BDI compared to the control (only ER) samples. Conclusions Based on the research outcome, the BDI could be used for biomaterials application, particularly tooth dental implantation. Graphical Abstract
ISSN:1865-1569
1865-1550
1865-1569
DOI:10.1007/s10006-024-01252-z