Ceftriaxone resistance in Neisseria gonorrhoeae associated with the penA-60.001 allele in Hanoi, Viet Nam

The prevalence of ceftriaxone resistance in N gonorrhoeae is highest in the Western Pacific region.1 Many of the N gonorrhoeae infections associated with high minimum inhibitory concentrations (MICs) to ceftriaxone reported in the USA, the UK, and the rest of Europe carry the penA-60.001 allele, whi...

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Bibliographic Details
Published in:The Lancet infectious diseases 2024-06, Vol.24 (6), p.e351-e352
Main Authors: Adamson, Paul C, Hieu, Vu N, Nhung, Pham H, Whiley, DM, Chau, TM
Format: Article
Language:English
Subjects:
Alleles
Antimicrobial agents
Ceftriaxone
Data collection
Gonorrhea
Mutation
Surveillance
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Summary:The prevalence of ceftriaxone resistance in N gonorrhoeae is highest in the Western Pacific region.1 Many of the N gonorrhoeae infections associated with high minimum inhibitory concentrations (MICs) to ceftriaxone reported in the USA, the UK, and the rest of Europe carry the penA-60.001 allele, which is associated with ceftriaxone resistance and was first detected in the Western Pacific region.2,3,6 The Enhanced Gonococcal Surveillance Programme in Cambodia recently reported 29 (38%) of 76 urethral isolates collected from 2021–22 were associated with ceftriaxone MICs of 0·125 mg/L or more.4 Moreover, all of those resistant isolates harbored the penA-60.001 allele. From January through to December, 2023, all isolates at the Hanoi Medical University Hospital (Hanoi, Viet Nam) were selected for antibiotic susceptibility testing (figure). The funder had no role in the data collection, analysis, or interpretation, or the decision to submit to publication.
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(24)00230-5