Asymptomatic parasitemia and RTS,S vaccine efficacy

The molecular detection of new infections as an outcome was done using two polymorphic gene loci of Plasmodium falciparum, the C-terminus coding region of the circumsporozoite protein and a coding region of the gene for the antigen serine repeat antigen 2 (SERA2). SERA2 is a member of the conserved...

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Bibliographic Details
Published in:The Lancet infectious diseases 2024-09, Vol.24 (9), p.942-944
Main Authors: Arisue, Nobuko, Palacpac, Nirianne Marie Q
Format: Article
Language:English
Subjects:
Antigens
Asymptomatic
Blood
C-Terminus
Circumsporozoite protein
Clinical trials
Genes
Genotyping
Haplotypes
Humans
Infections
Malaria
Malaria Vaccines - administration & dosage
Malaria Vaccines - immunology
Malaria, Falciparum - prevention & control
Parasitemia
Parasites
Parasitic diseases
Plasmodium falciparum
Proteins
SERA gene
Serine repeat antigen
Vaccine Efficacy
Vaccines
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Summary:The molecular detection of new infections as an outcome was done using two polymorphic gene loci of Plasmodium falciparum, the C-terminus coding region of the circumsporozoite protein and a coding region of the gene for the antigen serine repeat antigen 2 (SERA2). SERA2 is a member of the conserved SERA gene family consisting of nine genes, and one of the gene products, the SERA5 protein, is being evaluated in clinical trials as a blood-stage vaccine.9 Having many alleles, these genes are suitable molecular markers for detecting new infections and establishing complexity of infections. [...]the parasite positivity rate by molecular detection was about 3% higher than by microscopic identification (14·0% [5078/35 456] vs 11·6% [4115/35 456]).5 Genotyping did indicate that RTS,S is able to block infections before the parasite can reach the blood-stage.
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(24)00214-7