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Metal organic framework-based polymeric hydrogel: A promising drug delivery vehicle for the treatment of breast cancer

[Display omitted] •A hybrid hydrogel is formed by combining CuBTC and PVA with borax serving as the crosslinking agent.•The hydrogel demonstrated injectable and self-healing properties, as confirmed through thixotropic analysis.•The hydrogel exhibited outstanding biocompatibility on both normal (HaC...

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Bibliographic Details
Published in:International journal of pharmaceutics 2024-06, Vol.658, p.124206-124206, Article 124206
Main Authors: Pandya, Ishani, Kumar, Sugam, Aswal, Vinod K., El Seoud, Omar, Assiri, Mohammed A., Malek, Naved
Format: Article
Language:English
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Summary:[Display omitted] •A hybrid hydrogel is formed by combining CuBTC and PVA with borax serving as the crosslinking agent.•The hydrogel demonstrated injectable and self-healing properties, as confirmed through thixotropic analysis.•The hydrogel exhibited outstanding biocompatibility on both normal (HaCaT) and breast cancer (MCF-7) cell lines.•The drug-loaded hydrogel provides a controlled and sustained release of the anti-cancer drug (5-Fluorouracil) in accordance with pH changes. The constraints associated with current cancer therapies have inspired scientists to develop advanced, precise, and safe drug delivery methods. These delivery systems boost treatment effectiveness, minimize harm to healthy cells, and combat cancer recurrence. To design advanced drug delivery vehicle with these character, in the present manuscript, we have designed a self-healing and injectable hybrid hydrogel through synergistically interacting metal organic framework, CuBTC with the poly(vinyl alcohol) (PVA). This hybrid hydrogel acts as a localized drug delivery system and was used to encapsulate and release the anticancer drug 5-Fluorouracil selectively at the targeted site in response to the physiological pH. The hydrogel was formed through transforming the gaussian coil like matrix of PVA-CuBTC into a three-dimensional network of hydrogel upon the addition of crosslinker; borax. The biocompatible character of the hydrogel was confirmed through cell viability test. The biocompatible hybrid hydrogel then was used to encapsulate and studied for the pH responsive release behavior of the anti-cancer drug, 5-FU. The in vitro cytotoxicity of the drug-loaded hydrogel was evaluated against MCF-7 and HeLa cells. The study confirms that the hybrid hydrogel is effective for targeted and sustained release of anticancer drugs at cancer sites.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2024.124206