Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin

• Published in: Bulletin of experimental biology and medicine 2024-03, Vol.176 (5), p.636-639
• Main Authors: Michurina, S. V., Svechnikova, N. N., Konenkov, V. I., Ishchenko, I. Yu, Arkhipov, S. A., Arkhipova, V. V.
• Format: Article
• Language: English
• Subjects: Adult; Antibodies; Biomedical and Life Sciences; Biomedicine; Blood vessels; Capillaries; Cell Biology; Dermis; Dermis - metabolism; Endothelium; Epidermis; Epidermis - metabolism; Extracellular matrix; Female; Fibroblasts; Fibroblasts - metabolism; Humans; Hyaluronic acid; Hyaluronic Acid - metabolism; Immunohistochemistry; Internal Medicine; Laboratory Medicine; Ligands; Lymphatic system; Lymphatic System - metabolism; Lymphatic Vessels - metabolism; Male; Metabolism; Pathology; Skin; Skin - metabolism; Smooth muscle; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-024-06083-2

Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1 + staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.