Harnessing polyelectrolyte complexes for precision cancer targeting: a comprehensive review

Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2024-05, Vol.41 (6), p.145, Article 145
Main Authors: Prajapati, Bhupendra G., Sharma, Jai Bharti, Sharma, Swapnil, Trivedi, Naitik D., Gaur, Mansi, Kapoor, Devesh U.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Cancer therapies
Cell cycle
Cell division
Chemical bonds
Drug delivery systems
Drug Delivery Systems - methods
Drugs
Electrolytes
Hematology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Microscopy
Molecular biology
Nanoparticles
Neoplasms - drug therapy
Neoplasms - metabolism
NMR
Nuclear magnetic resonance
Oncology
Pathology
Pharmaceutical industry
Pharmacy
Polyelectrolytes - chemistry
Polymers
Precision Medicine - methods
Proteins
Quantum dots
Review Article
Surfactants
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Summary:Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the interaction between oppositely charged entities, such as polymers, drugs, and combinations thereof. The polyelectrolyte complexes are highly appealing in cancer management, play an indispensable role in chemotherapy, crafting biodegradable, biocompatible 3D membranes, microcapsules, and nano-sized formulations. These versatile complexes are pivotal in designing controlled and targeted release drug delivery systems. The present review emphasizes on classification of polyelectrolyte complex along with their formation mechanisms. This review comprehensively explores the applications of polyelectrolyte complex, highlighting their efficacy in targeted drug delivery strategies for combating different forms of cancer. The innovative use of polyelectrolyte complex presents a potential breakthrough in cancer therapeutics, demonstrating their role in enhancing treatment precision and effectiveness. Graphical abstract
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-024-02354-0