Association of HBeAg decline rate from mid‐pregnancy to delivery with HBeAg seroconversion after delivery in hepatitis B virus‐infected mothers

There is still controversy about whether to continue antiviral therapy (AVT) after delivery, especially for pregnant women in the immune tolerance (IT) phase. In this study, a retrospective cohort study was conducted to explore the relationship between hepatitis B e antigen (HBeAg) decline rate (%)...

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Bibliographic Details
Published in:Journal of viral hepatitis 2024-08, Vol.31 (8), p.439-445
Main Authors: Zhong, Wenting, Zheng, Jie, Yao, Naijuan, Feng, Yali, Zhu, Yage, Jiao, Zhe, Yan, Lanzhi, Shi, Lei, He, Yingli, Chen, Tianyan
Format: Article
Language:English
Subjects:
Adult
Antigens
Antiviral agents
Antiviral Agents - therapeutic use
Cohort analysis
DNA viruses
Female
Hepatitis B
Hepatitis B - immunology
Hepatitis B e antigen
Hepatitis B e Antigens - blood
Hepatitis B surface antigen
Hepatitis B virus - immunology
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - immunology
Humans
Immunological tolerance
Infectious Disease Transmission, Vertical - prevention & control
Postpartum
Postpartum Period
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - immunology
Retrospective Studies
ROC Curve
Sensitivity analysis
Seroconversion
Young Adult
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Summary:There is still controversy about whether to continue antiviral therapy (AVT) after delivery, especially for pregnant women in the immune tolerance (IT) phase. In this study, a retrospective cohort study was conducted to explore the relationship between hepatitis B e antigen (HBeAg) decline rate (%) from mid‐pregnancy to delivery and HBeAg seroconversion postpartum among patients using nucleos(t)ide analogs (NAs) to prevent mother‐to‐child transmission (MTCT), with the goal of identifying the ideal candidates for postpartum AVT continuation. This retrospective cohort study included 151 postpartum women. Univariate and multivariable logistic regression analyses were conducted to assess the association between the HBeAg decline rate (%) from mid‐pregnancy to delivery and HBeAg seroconversion postpartum. Receiver operating characteristic (ROC) analysis was utilized to evaluate the predictive capacity of the HBeAg decline rate (%) and determine the optimal cut‐off point. The univariate analysis revealed a significant association between the HBeAg decline rate (%) and HBeAg seroconversion postpartum (OR 1.068, 95% CI: 1.034–1.103, p 
ISSN:1352-0504
1365-2893
1365-2893
DOI:10.1111/jvh.13948