Templated Synthesis of Copper Nanoclusters with a Hybrid Lysozyme-Polymer Material for Enhanced Fluorescence

Hybrid materials that combine organic polymers and biomacromolecules offer unique opportunities for precisely controlling 3D chemical environments. Although biological or organic templates have been separately used to control the growth of inorganic nanoclusters, hybrid structures represent a relati...

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Bibliographic Details
Published in:Bioconjugate chemistry 2024-06, Vol.35 (6), p.732-736
Main Authors: Larkin, James O., Cheng, Zhihua, Arefeayne, Yafet, Segatori, Laura, Jones, Matthew R., Ball, Zachary T.
Format: Article
Language:English
Subjects:
Biocompatibility
Copper
Copper - chemistry
Fluorescence
Fluorescent Dyes - chemistry
Hybrid structures
Lysozyme
Metal Nanoparticles - chemistry
Muramidase - chemistry
Nanoclusters
Polymers
Polymers - chemistry
Synthesis
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Summary:Hybrid materials that combine organic polymers and biomacromolecules offer unique opportunities for precisely controlling 3D chemical environments. Although biological or organic templates have been separately used to control the growth of inorganic nanoclusters, hybrid structures represent a relatively unexplored approach to tailoring nanocluster properties. Here, we demonstrate that a molecularly defined lysozyme–polymer resin material acts as a structural scaffold for the synthesis of copper nanoclusters (CuNCs) with well controlled size distributions. The resulting CuNCs have significantly enhanced fluorescence compared with syntheses based on polymeric or biological templates alone. The synergistic approach described here is appealing for the synthesis of biocompatible fluorescent labels with improved photostability.
ISSN:1043-1802
1520-4812
1520-4812
DOI:10.1021/acs.bioconjchem.4c00058