Association between triglyceride glucose index and cognitive decline: A meta-analysis

The triglyceride glucose (TyG) index, a novel surrogate indicator for insulin resistance (IR), is believed to be associated with various diseases. However, its connection with cognitive decline remains controversy. The PubMed, EMBASE, Cochrane Library, Web of Science, and Medline databases were syst...

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Bibliographic Details
Published in:Journal of affective disorders 2024-08, Vol.359, p.70-77
Main Authors: Liu, Yuqin, Yang, Xingxiang, Gao, Jie, Xie, Chenqi, Tian, Chunyan, Gao, Tianlin
Format: Article
Language:English
Subjects:
Blood Glucose - analysis
Cognitive decline
Cognitive Dysfunction - blood
Cross-Sectional Studies
Female
Humans
Insulin Resistance
Male
Meta-analysis
Risk Factors
Triglyceride glucose index
Triglycerides - blood
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Summary:The triglyceride glucose (TyG) index, a novel surrogate indicator for insulin resistance (IR), is believed to be associated with various diseases. However, its connection with cognitive decline remains controversy. The PubMed, EMBASE, Cochrane Library, Web of Science, and Medline databases were systematically searched up to October 2023 to assess the association between the TyG index and the risk of cognitive decline. Effect estimates and 95 % confidence intervals (CIs) were calculated using a random-effects model. Our review included 3 cohort studies and 9 case-control/cross-sectional studies with a total of 5,603,350 participants. In comparison to a low TyG index, a higher TyG index was connected to an elevated risk of cognitive decline (RR/HR = 1.14, 95 % CI [1.11, 1.17], P 
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.05.049