Formulation of sumatriptan succinate orodispersible tablets using chitosan and sodium starch glycolate for immediate migraine relief

• Published in: Pakistan journal of pharmaceutical sciences 2024-01, Vol.37 (1), p.115-121
• Main Authors: Sahar, Tuba, Farid Hasan, Syed Muhammad, Ahmad, Salman Ashfaq, Bushra, Rabia, Rehman, Abdur, Noor, Rabia, Usman, Shahnaz, Razvi, Nighat, Hassan, Fouzia
• Format: Article
• Language: English
• Subjects: Administration, Oral; Analysis; Care and treatment; Chemical properties; Chemistry, Pharmaceutical; Chitin; Chitosan - chemistry; Dosage and administration; Drug Compounding; Drug therapy; Excipients - chemistry; Health aspects; Humans; Medical research; Medicine, Experimental; Migraine; Migraine Disorders - drug therapy; Nervous system diseases; Oral medication; Patient compliance; Solubility; Starch - administration & dosage; Starch - analogs & derivatives; Starch - chemistry; Sumatriptan; Sumatriptan - administration & dosage; Sumatriptan - chemistry; Tablets
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2024.37.1.REG.115-121.1

Migraine is one of the common neurological disease affecting around 23% of the Pakistani population. Prompt treatment is required to regain the functional ability of patients. The present study was designed to develop sumatriptan succinate orodispersible tablets that would quickly overcome acute migraine episodes using 2 full-factorial design. The chitosan and sodium starch glycolate were taken as independent variables; friability, disintegration, dispersion time and water absorption ratio as response variables. Eight trial formulations were generated by Design Expert® software. The main effect plots were used to check the interaction of formulations with response variables. All trial formulations showed good micromeritic properties in terms of angle of repose (19.59 -24.57 ), Carr's index (17.08-24.90%) and Hausner's ratio (1.20-1.33). The tablets wetted quickly (17.1- 39 sec) in dispersion medium, showed higher water absorption ratio (188-341 sec) and disintegrated quickly (13-20 sec) with an excellent dissolution rate (94-99%). The main effect plots show interactions between the independent variables against most of the study responses. A 2 full-factorial model was found to be effective in studying the influence of formulation variables on response parameters. Both chitosan and sodium starch glycolate can be used in combination to fabricate an effective orodispersible formulation of sumatriptan succinate.