The Epidemiological Burden of Neurovascular Pathology in Nigeria: A Systematic Review and Pooled Patient-Level Analysis

• Published in: World neurosurgery 2024-05, Vol.185, p.e243-e263
• Main Authors: Nischal, Shiva A., Badejo, Oluwakemi A., Trillo-Ordonez, Yesel, Oyemolade, Toyin A., Seas, Andreas, Malomo, Toluyemi A., Nwaribe, Evaristus E., Abu-Bonsrah, Nancy, Deng, Di D., Okere, Oghenekevwe E., Ogundeji, Olaniyi D., Oboh, Ena, Still, Megan E.H., Waguia-Kouam, Romaric, Asemota, Isaac, Oboh, Ehita N., Reddy, Padmavathi, Ugorji, Chiazam, Rahman, Raphia, von Isenburg, Megan, Fuller, Anthony T., Haglund, Michael M., Adeleye, Amos O., Ukachukwu, Alvan-Emeka K.
• Format: Article
• Language: English
• Subjects: Cerebrovascular Disorders - epidemiology; Cerebrovascular Disorders - surgery; Epidemiology; Humans; Male; Middle Aged; Neurosurgical Procedures; Neurovascular disease; Nigeria; Nigeria - epidemiology; Systematic review
• ISSN: 1878-8750; 1878-8769; 1878-8769
• DOI: 10.1016/j.wneu.2023.12.013

Vascular neurosurgery has developed significantly in Nigeria, but its burden and challenges remain unclear. This study systematically reviewed vascular neurosurgical literature from Nigeria. Four research databases and gray literature sources were searched from 1962–2021. ROBINS-I tool was used to assess risk of bias. Descriptive, narrative, and statistical analyses were conducted on all variables. Where appropriate, paired t-tests and Chi-squared independence tests were used (α = 0.05). 56 articles were included and 3203 patients pooled for analysis. Risk of bias was moderate-high. Most articles were published over the last 20 years with retrospective cohort studies and case reports being the most common study designs. The cohort had a relatively even gender split and an average age of 49 years (±22). Cerebrovascular accidents accounted for over 85% of diagnoses, with most etiologies being traumatic. Headache and motor deficit were the most prevalent clinical features. X-ray and carotid angiography were the most commonly reported imaging modalities, closely followed by computed tomography (CT) and CT angiography. The top two radiological diagnoses were ischemic cerebrovascular disease and intracerebral hematoma. Aneurysmal clipping and hematoma evacuation were the most commonly reported treatment modalities. Outcome at last follow-up was favorable in 48%. The mortality rate was 6%. Post-treatment complications included chest infection and rebleeding. This study illustrates the epidemiological burden of neurovascular pathology (based on the available data in published literature) in Nigeria, and raises awareness amongst service providers and researchers of the attendant challenges and epochal trends seen within vascular neurosurgery in Nigeria.