Crotonoids A–H, Labdane‐Type Diterpenoids with Anti‐Inflammatory Activity from Croton Sublyratus

Croton sublyratus (Euphorbiaceae) is a traditional medicinal plant used by the Thai populace to treat helminthic infections and dermatologic conditions. In present study, eight new labdane‐type diterpenoids, crotonoids A–H (1–8) and one known analogue (9) were isolated from the aerial parts of C. su...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2024-08, Vol.21 (8), p.e202401089-n/a
Main Authors: Qi, Jing‐Jing, Li, Ying, Fu, Rui‐Yao, Liu, Qun‐Fang, Zhao, Jin‐Xin, Yue, Jian‐Min
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory
Anti-inflammatory agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Circular dichroism
Croton - chemistry
Croton sublyratus
Crystallography, X-Ray
Data analysis
Dichroism
Diterpenes
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Dose-Response Relationship, Drug
Herbal medicine
Inflammation
labdane-type diterpenoids
Lipopolysaccharides
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
Medicinal plants
Mice
Models, Molecular
Molecular Conformation
Molecular Structure
nitric oxide
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Nitric Oxide - metabolism
norditerpenoids
RAW 264.7 Cells
X-ray diffraction
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Croton sublyratus (Euphorbiaceae) is a traditional medicinal plant used by the Thai populace to treat helminthic infections and dermatologic conditions. In present study, eight new labdane‐type diterpenoids, crotonoids A–H (1–8) and one known analogue (9) were isolated from the aerial parts of C. sublyratus. Compounds 6 and 7 belong to the rare class of 14,15‐dinor‐labdane diterpenoids. Compound 8 exhibited a rare 14,15,17‐trinor‐labdane skeleton. The structures of all these diterpenoids were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single‐crystal X‐ray diffraction analysis. Compound 9 exhibited moderate anti‐inflammatory activity via the inhibition of NO production in lipopolysaccharide‐induced RAW 264.7 cells.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202401089