Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose

• Published in: International journal of neuroscience 2024-05, p.1-8
• Main Authors: Flores-Rabasa, R, González-Almazán, J A, Cortés-Contreras, Ana Paula, Méndez-García, L A, Velasco, F, Navarro-Olvera, J L, Aguado-Carrillo, G, Benítez-Gasca, A, Gómez-Apo, E, Carrillo-Ruiz, J D
• Format: Article
• Language: English
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.1080/00207454.2024.2352780

This clinical, analytical, retro-prospective, auto-controlled, not randomized, and not blinded study, aimed to investigate the association of changes in the serum glucose levels with the pre-and-post changes in the size tumor in mm in the Non-Functional pituitary adenomas. Pre-and post-surgical MRI, as well as the measurements in the serum glucose levels and immunohistochemical techniques were performed in all the patients in the study, with a mean followed-up until 208.57 days. A comparison was made between the reductions in tumor size of hormonally active pituitary adenomas (HSPAs) vs NFPAs. Seventy-four patients were included in this study, of whom, 46 were NFPAs. The decrease in the NFPAs tumor size after surgery was statistically significant ( 0.0001 The Mean of the differences of both type of tumors in mm were -9552 ± 10287. Pre-surgery, the mean of the HSPAs were 8.923 ± 2.078; and the NFPAs were 14.161 ± 1.912. The differences in the tumor size were statistically significant ( ). Post-surgical, the mean of the HSPAs were 2.079 ± 971, with a ( : and the NFPAs were 4.609 ± 1.205. After surgery of the NFPAs, most of the patients-maintained serum levels ≤ 100 mg/dL, with a statistical significance ( 0.0003). This study demonstrates for the first time the correlation between the presence of pre-and post- surgical changes in the NFPAs, with modifications in the levels of serum glucose, and the comparison, pre- and post-surgical between the tumor size of HSPAs and NFPAs.