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A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation
Objective To examine neonatal outcomes of infants with gastroschisis born
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| Published in: | Journal of perinatology 2024-09, Vol.44 (9), p.1335-1339 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 1339 |
| container_issue | 9 |
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| container_title | Journal of perinatology |
| container_volume | 44 |
| creator | Pugh, C. Preston Zaniletti, Isabella Miquel-Verges, Franscesca Nghiem-Rao, T. Hang Downey, L. Corbin Hightower, Hannah Grover, Theresa Murthy, Karna Riddle, Stefanie Acharya, Krishna |
| description | Objective
To examine neonatal outcomes of infants with gastroschisis born |
| doi_str_mv | 10.1038/s41372-024-01974-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3055449341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3055449341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-dadbdfcba17a948c46685072ef90e21aee8e7140ca943d85788cbae38bede5fd3</originalsourceid><addsrcrecordid>eNp9kU1LxDAQhoMo7rr6BzxIwIuXaNKkTfYo4hcseNFzSNPpbte2WZMU2X9v9kMFD0JgIO8zM8z7InTO6DWjXN0EwbjMCM0EoWwqBVEHaMyELEieC36IxlQKThQXxQidhLCkdCPKYzTiSgox5cUYNbe4G9rYWOgjeNyZaBdQEesWzkdsetOuQxOwq_HchOhdsItm-zFE6zoIuOnTq00fAy6d73EJtfOAeYY_Ad4DnkOIJjauP0VHtWkDnO3rBL093L_ePZHZy-Pz3e2MWJ4VkVSmKqvaloZJMxXKiqJQOZUZ1FMKGTMACiQT1CaVVyqXSiUYuCqhgryu-ARd7eauvPsY0nbdNcFC25oe3BA0p8mddHwyb4Iu_6BLN_h0c6IYTebmOVeJynaUTecHD7Ve-aYzfq0Z1Zsg9C4InYLQ2yD0puliP3ooO6h-Wr6dTwDfASFJ_Rz87-5_xn4ByBuVag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3101375538</pqid></control><display><type>article</type><title>A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation</title><source>Nexis UK</source><source>Springer Link</source><creator>Pugh, C. Preston ; Zaniletti, Isabella ; Miquel-Verges, Franscesca ; Nghiem-Rao, T. Hang ; Downey, L. Corbin ; Hightower, Hannah ; Grover, Theresa ; Murthy, Karna ; Riddle, Stefanie ; Acharya, Krishna</creator><creatorcontrib>Pugh, C. Preston ; Zaniletti, Isabella ; Miquel-Verges, Franscesca ; Nghiem-Rao, T. Hang ; Downey, L. Corbin ; Hightower, Hannah ; Grover, Theresa ; Murthy, Karna ; Riddle, Stefanie ; Acharya, Krishna ; Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group ; the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</creatorcontrib><description>Objective
To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis.
Study design
Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.
Results
The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%,
p
= 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge.
Conclusion
Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-024-01974-8</identifier><identifier>PMID: 38744936</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/700/1720 ; Case-Control Studies ; Cohort analysis ; Comorbidity ; Enterocolitis, Necrotizing - epidemiology ; Enterocolitis, Necrotizing - mortality ; Female ; Gastroschisis - epidemiology ; Gastroschisis - mortality ; Gestation ; Gestational Age ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - mortality ; Infants ; Intensive Care Units, Neonatal ; Length of Stay - statistics & numerical data ; Male ; Medicine ; Medicine & Public Health ; Mortality ; Neonates ; Pediatric Surgery ; Pediatrics ; Retrospective Studies</subject><ispartof>Journal of perinatology, 2024-09, Vol.44 (9), p.1335-1339</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-dadbdfcba17a948c46685072ef90e21aee8e7140ca943d85788cbae38bede5fd3</cites><orcidid>0000-0002-6073-4669 ; 0000-0003-2504-5419 ; 0000-0001-9945-6689 ; 0000-0003-4364-7165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38744936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pugh, C. Preston</creatorcontrib><creatorcontrib>Zaniletti, Isabella</creatorcontrib><creatorcontrib>Miquel-Verges, Franscesca</creatorcontrib><creatorcontrib>Nghiem-Rao, T. Hang</creatorcontrib><creatorcontrib>Downey, L. Corbin</creatorcontrib><creatorcontrib>Hightower, Hannah</creatorcontrib><creatorcontrib>Grover, Theresa</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Riddle, Stefanie</creatorcontrib><creatorcontrib>Acharya, Krishna</creatorcontrib><creatorcontrib>Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</creatorcontrib><creatorcontrib>the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</creatorcontrib><title>A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis.
Study design
Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.
Results
The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%,
p
= 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge.
Conclusion
Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.</description><subject>692/308/409</subject><subject>692/700/1720</subject><subject>Case-Control Studies</subject><subject>Cohort analysis</subject><subject>Comorbidity</subject><subject>Enterocolitis, Necrotizing - epidemiology</subject><subject>Enterocolitis, Necrotizing - mortality</subject><subject>Female</subject><subject>Gastroschisis - epidemiology</subject><subject>Gastroschisis - mortality</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Premature, Diseases - mortality</subject><subject>Infants</subject><subject>Intensive Care Units, Neonatal</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Neonates</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><issn>0743-8346</issn><issn>1476-5543</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LxDAQhoMo7rr6BzxIwIuXaNKkTfYo4hcseNFzSNPpbte2WZMU2X9v9kMFD0JgIO8zM8z7InTO6DWjXN0EwbjMCM0EoWwqBVEHaMyELEieC36IxlQKThQXxQidhLCkdCPKYzTiSgox5cUYNbe4G9rYWOgjeNyZaBdQEesWzkdsetOuQxOwq_HchOhdsItm-zFE6zoIuOnTq00fAy6d73EJtfOAeYY_Ad4DnkOIJjauP0VHtWkDnO3rBL093L_ePZHZy-Pz3e2MWJ4VkVSmKqvaloZJMxXKiqJQOZUZ1FMKGTMACiQT1CaVVyqXSiUYuCqhgryu-ARd7eauvPsY0nbdNcFC25oe3BA0p8mddHwyb4Iu_6BLN_h0c6IYTebmOVeJynaUTecHD7Ve-aYzfq0Z1Zsg9C4InYLQ2yD0puliP3ooO6h-Wr6dTwDfASFJ_Rz87-5_xn4ByBuVag</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Pugh, C. Preston</creator><creator>Zaniletti, Isabella</creator><creator>Miquel-Verges, Franscesca</creator><creator>Nghiem-Rao, T. Hang</creator><creator>Downey, L. Corbin</creator><creator>Hightower, Hannah</creator><creator>Grover, Theresa</creator><creator>Murthy, Karna</creator><creator>Riddle, Stefanie</creator><creator>Acharya, Krishna</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6073-4669</orcidid><orcidid>https://orcid.org/0000-0003-2504-5419</orcidid><orcidid>https://orcid.org/0000-0001-9945-6689</orcidid><orcidid>https://orcid.org/0000-0003-4364-7165</orcidid></search><sort><creationdate>202409</creationdate><title>A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation</title><author>Pugh, C. Preston ; Zaniletti, Isabella ; Miquel-Verges, Franscesca ; Nghiem-Rao, T. Hang ; Downey, L. 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Preston</creatorcontrib><creatorcontrib>Zaniletti, Isabella</creatorcontrib><creatorcontrib>Miquel-Verges, Franscesca</creatorcontrib><creatorcontrib>Nghiem-Rao, T. Hang</creatorcontrib><creatorcontrib>Downey, L. Corbin</creatorcontrib><creatorcontrib>Hightower, Hannah</creatorcontrib><creatorcontrib>Grover, Theresa</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Riddle, Stefanie</creatorcontrib><creatorcontrib>Acharya, Krishna</creatorcontrib><creatorcontrib>Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</creatorcontrib><creatorcontrib>the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pugh, C. Preston</au><au>Zaniletti, Isabella</au><au>Miquel-Verges, Franscesca</au><au>Nghiem-Rao, T. Hang</au><au>Downey, L. Corbin</au><au>Hightower, Hannah</au><au>Grover, Theresa</au><au>Murthy, Karna</au><au>Riddle, Stefanie</au><au>Acharya, Krishna</au><aucorp>Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</aucorp><aucorp>the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>44</volume><issue>9</issue><spage>1335</spage><epage>1339</epage><pages>1335-1339</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis.
Study design
Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.
Results
The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%,
p
= 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge.
Conclusion
Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38744936</pmid><doi>10.1038/s41372-024-01974-8</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6073-4669</orcidid><orcidid>https://orcid.org/0000-0003-2504-5419</orcidid><orcidid>https://orcid.org/0000-0001-9945-6689</orcidid><orcidid>https://orcid.org/0000-0003-4364-7165</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2024-09, Vol.44 (9), p.1335-1339 |
| issn | 0743-8346 1476-5543 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3055449341 |
| source | Nexis UK; Springer Link |
| subjects | 692/308/409 692/700/1720 Case-Control Studies Cohort analysis Comorbidity Enterocolitis, Necrotizing - epidemiology Enterocolitis, Necrotizing - mortality Female Gastroschisis - epidemiology Gastroschisis - mortality Gestation Gestational Age Hospitals Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - epidemiology Infant, Premature, Diseases - mortality Infants Intensive Care Units, Neonatal Length of Stay - statistics & numerical data Male Medicine Medicine & Public Health Mortality Neonates Pediatric Surgery Pediatrics Retrospective Studies |
| title | A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation |
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