Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation

• Published in: Current cardiology reports 2024-07, Vol.26 (7), p.705-715
• Main Authors: Darwish, Amr, Bersali, Akila, Saeed, Mujtaba, Dhore, Aneesh, Maragiannis, Dimitrios, El-Tallawi, K. Carlos, Shah, Dipan J.
• Format: Article
• Language: English
• Subjects: Cardiac PET; Cardiology; Fibrosis; Humans; Magnetic Resonance Imaging, Cine - methods; Medicine; Medicine & Public Health; Mitral Valve - diagnostic imaging; Mitral Valve - pathology; Mitral Valve - physiopathology; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - physiopathology; MRI; MRI (P Cremer; Myocardium - pathology; Prognosis; Section Editor; Severity of Illness Index; Topical Collection on Cardiac PET; Ventricular Remodeling
• ISSN: 1523-3782; 1534-3170; 1534-3170
• DOI: 10.1007/s11886-024-02069-8

Purpose of Review This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR. Recent Findings Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues. Summary Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention.