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Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation
Purpose of Review This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide differ...
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| Published in: | Current cardiology reports 2024-07, Vol.26 (7), p.705-715 |
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| container_end_page | 715 |
| container_issue | 7 |
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| container_title | Current cardiology reports |
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| creator | Darwish, Amr Bersali, Akila Saeed, Mujtaba Dhore, Aneesh Maragiannis, Dimitrios El-Tallawi, K. Carlos Shah, Dipan J. |
| description | Purpose of Review
This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR.
Recent Findings
Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues.
Summary
Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention. |
| doi_str_mv | 10.1007/s11886-024-02069-8 |
| format | article |
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This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR.
Recent Findings
Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues.
Summary
Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention.</description><identifier>ISSN: 1523-3782</identifier><identifier>ISSN: 1534-3170</identifier><identifier>EISSN: 1534-3170</identifier><identifier>DOI: 10.1007/s11886-024-02069-8</identifier><identifier>PMID: 38748329</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiac PET ; Cardiology ; Fibrosis ; Humans ; Magnetic Resonance Imaging, Cine - methods ; Medicine ; Medicine & Public Health ; Mitral Valve - diagnostic imaging ; Mitral Valve - pathology ; Mitral Valve - physiopathology ; Mitral Valve Insufficiency - diagnostic imaging ; Mitral Valve Insufficiency - physiopathology ; MRI ; MRI (P Cremer ; Myocardium - pathology ; Prognosis ; Section Editor ; Severity of Illness Index ; Topical Collection on Cardiac PET ; Ventricular Remodeling</subject><ispartof>Current cardiology reports, 2024-07, Vol.26 (7), p.705-715</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-1482bb495abcf972212ac95e5ddb0aa90b39377789c978c5b7ee73239e6099ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38748329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Darwish, Amr</creatorcontrib><creatorcontrib>Bersali, Akila</creatorcontrib><creatorcontrib>Saeed, Mujtaba</creatorcontrib><creatorcontrib>Dhore, Aneesh</creatorcontrib><creatorcontrib>Maragiannis, Dimitrios</creatorcontrib><creatorcontrib>El-Tallawi, K. Carlos</creatorcontrib><creatorcontrib>Shah, Dipan J.</creatorcontrib><title>Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation</title><title>Current cardiology reports</title><addtitle>Curr Cardiol Rep</addtitle><addtitle>Curr Cardiol Rep</addtitle><description>Purpose of Review
This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR.
Recent Findings
Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues.
Summary
Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention.</description><subject>Cardiac PET</subject><subject>Cardiology</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitral Valve - diagnostic imaging</subject><subject>Mitral Valve - pathology</subject><subject>Mitral Valve - physiopathology</subject><subject>Mitral Valve Insufficiency - diagnostic imaging</subject><subject>Mitral Valve Insufficiency - physiopathology</subject><subject>MRI</subject><subject>MRI (P Cremer</subject><subject>Myocardium - pathology</subject><subject>Prognosis</subject><subject>Section Editor</subject><subject>Severity of Illness Index</subject><subject>Topical Collection on Cardiac PET</subject><subject>Ventricular Remodeling</subject><issn>1523-3782</issn><issn>1534-3170</issn><issn>1534-3170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoOl5ewIVk6WKquTSTZDkM3kBRRl2HpD1To512TFpl3t5oVXDjIuTA-c4P_4fQISUnlBB5GilVapIRlqdHJjpTG2hEBc8zTiXZ_JwZz7hUbAftxvhMEkVkvo12uJK54kyP0Ms0RojRNxWeQ9WHyne2822D7-ENgu_WYzwt0xQh7ZdtCXVCx9g2JT73LrTRR_zuuyc8u5lj3-C74Jc2rPGN74Kt_2buo62FrSMcfP976PH87GF2mV3fXlzNptdZwbTqMpor5lyuhXXFQkvGKLOFFiDK0hFrNXFccyml0oWWqhBOAkjOuIYJ0do6voeOh9xVaF97iJ1Z-lhAXdsG2j4aToTIBWeSJZQNaJGqxAALsxoKGErMp2QzSDZJsvmSbFQ6OvrO790Syt-TH6sJ4AMQ06qpIJjntg9N6vxf7Ac-p4hY</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Darwish, Amr</creator><creator>Bersali, Akila</creator><creator>Saeed, Mujtaba</creator><creator>Dhore, Aneesh</creator><creator>Maragiannis, Dimitrios</creator><creator>El-Tallawi, K. Carlos</creator><creator>Shah, Dipan J.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation</title><author>Darwish, Amr ; Bersali, Akila ; Saeed, Mujtaba ; Dhore, Aneesh ; Maragiannis, Dimitrios ; El-Tallawi, K. Carlos ; Shah, Dipan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-1482bb495abcf972212ac95e5ddb0aa90b39377789c978c5b7ee73239e6099ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiac PET</topic><topic>Cardiology</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging, Cine - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitral Valve - diagnostic imaging</topic><topic>Mitral Valve - pathology</topic><topic>Mitral Valve - physiopathology</topic><topic>Mitral Valve Insufficiency - diagnostic imaging</topic><topic>Mitral Valve Insufficiency - physiopathology</topic><topic>MRI</topic><topic>MRI (P Cremer</topic><topic>Myocardium - pathology</topic><topic>Prognosis</topic><topic>Section Editor</topic><topic>Severity of Illness Index</topic><topic>Topical Collection on Cardiac PET</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Darwish, Amr</creatorcontrib><creatorcontrib>Bersali, Akila</creatorcontrib><creatorcontrib>Saeed, Mujtaba</creatorcontrib><creatorcontrib>Dhore, Aneesh</creatorcontrib><creatorcontrib>Maragiannis, Dimitrios</creatorcontrib><creatorcontrib>El-Tallawi, K. Carlos</creatorcontrib><creatorcontrib>Shah, Dipan J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current cardiology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Darwish, Amr</au><au>Bersali, Akila</au><au>Saeed, Mujtaba</au><au>Dhore, Aneesh</au><au>Maragiannis, Dimitrios</au><au>El-Tallawi, K. Carlos</au><au>Shah, Dipan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation</atitle><jtitle>Current cardiology reports</jtitle><stitle>Curr Cardiol Rep</stitle><addtitle>Curr Cardiol Rep</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>26</volume><issue>7</issue><spage>705</spage><epage>715</epage><pages>705-715</pages><issn>1523-3782</issn><issn>1534-3170</issn><eissn>1534-3170</eissn><abstract>Purpose of Review
This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR.
Recent Findings
Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues.
Summary
Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38748329</pmid><doi>10.1007/s11886-024-02069-8</doi><tpages>11</tpages></addata></record> |
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| subjects | Cardiac PET Cardiology Fibrosis Humans Magnetic Resonance Imaging, Cine - methods Medicine Medicine & Public Health Mitral Valve - diagnostic imaging Mitral Valve - pathology Mitral Valve - physiopathology Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - physiopathology MRI MRI (P Cremer Myocardium - pathology Prognosis Section Editor Severity of Illness Index Topical Collection on Cardiac PET Ventricular Remodeling |
| title | Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation |
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