Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins

Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL)....

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Bibliographic Details
Published in:Ultrastructural pathology 2024-07, Vol.48 (4), p.1-309
Main Authors: Wang, Bangchen, Schub, Micah, Robinson, Derrick L, Howell, David N
Format: Article
Language:English
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Summary:Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.
ISSN:0191-3123
1521-0758
1521-0758
DOI:10.1080/01913123.2024.2356112