Copper-Catalyzed [4+1+1] Annulation of Ammonium Salts and Anthranils: Synthesis of 2,3-Diaroylquinolines

A copper­(I)-catalyzed protocol is developed for the synthesis of various 2,3-diaroylquinolines starting from achiral ammonium salts and anthranils through [4+1+1] annulation. Using copper­(I) chloride as the sole catalyst, this reaction is featured with easily available starting materials, broad su...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-05, Vol.89 (11), p.7446-7454
Main Authors: Yang, Jia-Cheng, Ma, Cheng-Wei, Liao, Mao-Lin, Li, Ping-Gui, Zou, Liang-Hua
Format: Article
Language:English
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Summary:A copper­(I)-catalyzed protocol is developed for the synthesis of various 2,3-diaroylquinolines starting from achiral ammonium salts and anthranils through [4+1+1] annulation. Using copper­(I) chloride as the sole catalyst, this reaction is featured with easily available starting materials, broad substrate scope, good yields and simple reaction conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02851