Linking Aging to Cancer: The Role of Chromatin Biology

Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the centr...

Full description

Saved in:
Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2024-07, Vol.79 (7)
Main Authors: Corveleyn, Laura, Sen, Payel, Adams, Peter, Sidoli, Simone
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - physiology
Animals
Cellular Senescence - genetics
Cellular Senescence - physiology
Chromatin - genetics
Chromatin - metabolism
Chromatin Assembly and Disassembly - genetics
DNA Methylation
Epigenesis, Genetic
Genomic Instability - genetics
Histones - metabolism
Humans
Neoplasms - genetics
Protein Processing, Post-Translational
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 7
container_start_page
container_title The journals of gerontology. Series A, Biological sciences and medical sciences
container_volume 79
creator Corveleyn, Laura
Sen, Payel
Adams, Peter
Sidoli, Simone
description Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.
doi_str_mv 10.1093/gerona/glae133
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3056662217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3056662217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c180t-38297fd9663997be44a3c92ac77b3b2daa24bf95fdca2106cf33265684f57ed3</originalsourceid><addsrcrecordid>eNo9kD1PwzAQhi0EoqWwMqKMLGltX2zHbCXiS4qEhDqwWY5jp4EkLnY69N_TqoUb7t7huXd4ELoleE6whEVjgx_0oum0JQBnaEoEy1MG7PN8n7GQKcOYT9BVjF_4MIxeognkghPgdIp42Q7f7dAky-awR58UejA2PCSrtU0-fGcT75JiHXyvx3ZIHlvf-WZ3jS6c7qK9Od0ZWj0_rYrXtHx_eSuWZWpIjscUciqFqyXnIKWobJZpMJJqI0QFFa21plnlJHO10ZRgbhwA5YznmWPC1jBD98faTfA_WxtH1bfR2K7Tg_XbqAAzzjmlROzR-RE1wccYrFOb0PY67BTB6qBKHVWpk6r9w92pe1v1tv7H_9zAL79eZVs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3056662217</pqid></control><display><type>article</type><title>Linking Aging to Cancer: The Role of Chromatin Biology</title><source>Oxford Journals Online</source><creator>Corveleyn, Laura ; Sen, Payel ; Adams, Peter ; Sidoli, Simone</creator><creatorcontrib>Corveleyn, Laura ; Sen, Payel ; Adams, Peter ; Sidoli, Simone</creatorcontrib><description>Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.</description><identifier>ISSN: 1079-5006</identifier><identifier>ISSN: 1758-535X</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glae133</identifier><identifier>PMID: 38761362</identifier><language>eng</language><publisher>United States</publisher><subject>Aging - genetics ; Aging - physiology ; Animals ; Cellular Senescence - genetics ; Cellular Senescence - physiology ; Chromatin - genetics ; Chromatin - metabolism ; Chromatin Assembly and Disassembly - genetics ; DNA Methylation ; Epigenesis, Genetic ; Genomic Instability - genetics ; Histones - metabolism ; Humans ; Neoplasms - genetics ; Protein Processing, Post-Translational</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2024-07, Vol.79 (7)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2809-0901</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38761362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corveleyn, Laura</creatorcontrib><creatorcontrib>Sen, Payel</creatorcontrib><creatorcontrib>Adams, Peter</creatorcontrib><creatorcontrib>Sidoli, Simone</creatorcontrib><title>Linking Aging to Cancer: The Role of Chromatin Biology</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.</description><subject>Aging - genetics</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Cellular Senescence - genetics</subject><subject>Cellular Senescence - physiology</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Chromatin Assembly and Disassembly - genetics</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Genomic Instability - genetics</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Neoplasms - genetics</subject><subject>Protein Processing, Post-Translational</subject><issn>1079-5006</issn><issn>1758-535X</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kD1PwzAQhi0EoqWwMqKMLGltX2zHbCXiS4qEhDqwWY5jp4EkLnY69N_TqoUb7t7huXd4ELoleE6whEVjgx_0oum0JQBnaEoEy1MG7PN8n7GQKcOYT9BVjF_4MIxeognkghPgdIp42Q7f7dAky-awR58UejA2PCSrtU0-fGcT75JiHXyvx3ZIHlvf-WZ3jS6c7qK9Od0ZWj0_rYrXtHx_eSuWZWpIjscUciqFqyXnIKWobJZpMJJqI0QFFa21plnlJHO10ZRgbhwA5YznmWPC1jBD98faTfA_WxtH1bfR2K7Tg_XbqAAzzjmlROzR-RE1wccYrFOb0PY67BTB6qBKHVWpk6r9w92pe1v1tv7H_9zAL79eZVs</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Corveleyn, Laura</creator><creator>Sen, Payel</creator><creator>Adams, Peter</creator><creator>Sidoli, Simone</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2809-0901</orcidid></search><sort><creationdate>20240701</creationdate><title>Linking Aging to Cancer: The Role of Chromatin Biology</title><author>Corveleyn, Laura ; Sen, Payel ; Adams, Peter ; Sidoli, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c180t-38297fd9663997be44a3c92ac77b3b2daa24bf95fdca2106cf33265684f57ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aging - genetics</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Cellular Senescence - genetics</topic><topic>Cellular Senescence - physiology</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>Chromatin Assembly and Disassembly - genetics</topic><topic>DNA Methylation</topic><topic>Epigenesis, Genetic</topic><topic>Genomic Instability - genetics</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Neoplasms - genetics</topic><topic>Protein Processing, Post-Translational</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corveleyn, Laura</creatorcontrib><creatorcontrib>Sen, Payel</creatorcontrib><creatorcontrib>Adams, Peter</creatorcontrib><creatorcontrib>Sidoli, Simone</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corveleyn, Laura</au><au>Sen, Payel</au><au>Adams, Peter</au><au>Sidoli, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linking Aging to Cancer: The Role of Chromatin Biology</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>79</volume><issue>7</issue><issn>1079-5006</issn><issn>1758-535X</issn><eissn>1758-535X</eissn><abstract>Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications, and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase in chromatin instability, loss of homeostasis, and decondensation. However, numerous publications have highlighted that the link between aging and chromatin changes is not nearly as linear as previously expected. This complex interplay of these epigenetic elements during the lifetime of an organism likely contributes to cellular senescence, genomic instability, and disease susceptibility. Yet, the causal links between these phenomena still need to be fully unraveled. In this perspective article, we discuss potential future directions of aging chromatin biology.</abstract><cop>United States</cop><pmid>38761362</pmid><doi>10.1093/gerona/glae133</doi><orcidid>https://orcid.org/0000-0003-2809-0901</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1079-5006
ispartof The journals of gerontology. Series A, Biological sciences and medical sciences, 2024-07, Vol.79 (7)
issn 1079-5006
1758-535X
1758-535X
language eng
recordid cdi_proquest_miscellaneous_3056662217
source Oxford Journals Online
subjects Aging - genetics
Aging - physiology
Animals
Cellular Senescence - genetics
Cellular Senescence - physiology
Chromatin - genetics
Chromatin - metabolism
Chromatin Assembly and Disassembly - genetics
DNA Methylation
Epigenesis, Genetic
Genomic Instability - genetics
Histones - metabolism
Humans
Neoplasms - genetics
Protein Processing, Post-Translational
title Linking Aging to Cancer: The Role of Chromatin Biology
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T10%3A45%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Linking%20Aging%20to%20Cancer:%20The%20Role%20of%20Chromatin%20Biology&rft.jtitle=The%20journals%20of%20gerontology.%20Series%20A,%20Biological%20sciences%20and%20medical%20sciences&rft.au=Corveleyn,%20Laura&rft.date=2024-07-01&rft.volume=79&rft.issue=7&rft.issn=1079-5006&rft.eissn=1758-535X&rft_id=info:doi/10.1093/gerona/glae133&rft_dat=%3Cproquest_cross%3E3056662217%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c180t-38297fd9663997be44a3c92ac77b3b2daa24bf95fdca2106cf33265684f57ed3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3056662217&rft_id=info:pmid/38761362&rfr_iscdi=true