FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in childhood. Although pre-operative cisplatin (CDDP)-based chemotherapy is often used in cases of HB, about 20％ of HB patients exhibit resistance to CDDP. Forkhead box protein M1 (FOXM1) and chromo-domain-helicase-DNA-binding protein 4 (C...

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Published in:Pathology, research and practice research and practice, 2024-06, Vol.258, p.155348-155348, Article 155348
Main Authors: Hino, Yuko, Kohashi, Kenichi, Tamaki, Akihiko, Kawakubo, Naonori, Hamada, Hiroshi, Fukuhara, Masahiro, Shibui, Yuichi, Tajiri, Tatsuro, Oda, Yoshinao
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Chemoresistance
Child
Child, Preschool
Chromo-domain-helicase-DNA-binding protein 4 (CHD4)
Cisplatin
Cisplatin - therapeutic use
Drug Resistance, Neoplasm
Female
Forkhead box protein M1 (FOXM1)
Forkhead Box Protein M1 - metabolism
Hepatoblastoma
Hepatoblastoma - drug therapy
Hepatoblastoma - metabolism
Hepatoblastoma - pathology
Humans
Infant
Liver Neoplasms - drug therapy
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism
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Summary:Hepatoblastoma (HB) is the most common malignant liver tumor in childhood. Although pre-operative cisplatin (CDDP)-based chemotherapy is often used in cases of HB, about 20％ of HB patients exhibit resistance to CDDP. Forkhead box protein M1 (FOXM1) and chromo-domain-helicase-DNA-binding protein 4 (CHD4) have been associated with CDDP resistance in various tumors. We here analyzed the immunohistochemical expression of FOXM1 and CHD4 in HB specimens of 33 patients (mean age: 20 months) post-chemotherapy. The differentiation of specimens was assessed using the digital pathology software QuPath®, and then the relation between the FOXM1 or CHD4 expression and the differentiation and various other clinicopathological parameters was investigated. The histological type was epithelial in 19 cases (57.6%) and mixed epithelial and mesenchymal in 14 cases (42.4%). Nine cases had only a fetal component, 1 case had only an embryonal component, 22 cases had both fetal and embryonal components, and 1 case had no viable tumor. Both the FOXM1 and CHD4 immunoexpressions were found significantly more frequently in the embryonal than fetal components (p
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2024.155348