Prognostic factors in Kaposi sarcoma, single centre experience

Background Kaposi sarcoma (KS) is a multicentric vascular and lymphatic neoplasm caused by human herpesvirus 8 (HHV‐8). It generally concerns the elderly and immunosuppressed population. Four major clinical types of KS have been described. The most common subtype is Classical KS (CKS). Objectives Ou...

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Bibliographic Details
Published in:Australasian journal of dermatology 2024-08, Vol.65 (5), p.444-450
Main Authors: Değerli, Ezgi, Oruç, Kerem, Şentürk Öztaş, Nihan, Alkan Şen, Gülin, Bedir, Şahin, Demirci, Nebi Serkan, Demirelli, Hulusi Fuat
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemotherapy
classic type kaposi
Female
Gender
Hemoglobin
Hemoglobins - analysis
Hemoglobins - metabolism
Herpes viruses
HHV‐8
Humans
Kaposi sarcoma
Kaposis sarcoma
Male
Medical prognosis
Middle Aged
Patients
Prognosis
Radiation therapy
Retrospective Studies
Sarcoma
Sarcoma, Kaposi - therapy
Sex Factors
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Survival
Survival Rate
Turkey - epidemiology
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Summary:Background Kaposi sarcoma (KS) is a multicentric vascular and lymphatic neoplasm caused by human herpesvirus 8 (HHV‐8). It generally concerns the elderly and immunosuppressed population. Four major clinical types of KS have been described. The most common subtype is Classical KS (CKS). Objectives Our retrospective study aimed to better define prognostic subgroups among patients with CKS, which is the most common in our country. Method Between 2014 and 2020, 43 patients with CKS were treated with local excision, radiotherapy and chemotherapy. Reviewed information included demographics, clinical features, laboratory findings, treatment responses and overall survival. Results During the follow‐up, eight patients (18.6%) died of CKS. The complete response rate was 46.5%, partial response and stable disease 51.2%, and progressive disease 2.3% of all patients. Gender, haemoglobin level at diagnosis, and disseminated involvement were prognostic factors affecting survival in all patients. Conclusion We confirmed that male gender, low haemoglobin levels, and disseminated involvement are associated with poor prognosis in CKS patients. It is the only Turkish study in which prognostic analysis was performed for this rare cancer.
ISSN:0004-8380
1440-0960
1440-0960
DOI:10.1111/ajd.14309