Efficacy of apremilast in hyperkeratotic hand and foot dermatitis: results from a randomized observer‐blinded comparative study

• Published in: International journal of dermatology 2024-11, Vol.63 (11), p.1535-1540
• Main Authors: Bhat, Kriti, Patra, Suman, Bhardwaj, Abhishek, Singh, Saurabh, Budania, Anil, Bains, Anupama, Saurabh, Suman
• Format: Article
• Language: English
• Subjects: Administration, Cutaneous; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; apremilast; Comparative studies; Corticoids; Corticosteroids; Dermatitis; Drug Therapy, Combination; Eczema; Effectiveness; Feet; Female; Flares; Foot Dermatoses - diagnosis; Foot Dermatoses - drug therapy; hand dermatitis; Hand Dermatoses - diagnosis; Hand Dermatoses - drug therapy; Humans; hyperkeratotic; Immunoglobulin A; Keratosis - diagnosis; Keratosis - drug therapy; Male; Middle Aged; mometasone; Mometasone Furoate - administration & dosage; Patients; Pruritus; Pruritus - diagnosis; Pruritus - drug therapy; Pruritus - etiology; Quality of Life; relapse; Severity of Illness Index; Single-Blind Method; Skin Cream - administration & dosage; Skin diseases; Steroids; Thalidomide - administration & dosage; Thalidomide - adverse effects; Thalidomide - analogs & derivatives; Thalidomide - therapeutic use; Treatment Outcome; Young Adult
• ISSN: 0011-9059; 1365-4632; 1365-4632
• DOI: 10.1111/ijd.17185

Background Hyperkeratotic hand and foot dermatitis significantly affects quality of life. Some patients respond suboptimally to topical corticosteroids and have multiple recurrences. Objective Our aim was to compare the efficacy and safety profile of apremilast and topical corticosteroid versus corticosteroid alone in hyperkeratotic hand and foot dermatitis. Methods This randomized controlled study involved 77 patients treated for 3 months. Group A (39 patients) received mometasone furoate 0.1% cream with oral apremilast 30 mg twice daily, and Group B (38 patients) received mometasone alone. They were assessed monthly using the Hand Eczema Clinical Severity Index (HECSI) and Visual Analogue Scale (VAS) scores for pruritus. Investigator Global Assessment (IGA) and Quality of Life in Hand Eczema Questionnaire (QOLHEQ) were conducted at the end of 3 months. Results The HECSI, VAS score, and QOLHEQ showed a significant decrease in both groups from baseline to the third month. Intergroup comparisons of HECSI failed to reach the significance level. When compared, patients receiving apremilast had significantly better improvement in the third month according to the Patient Global Assessment (PGA) and Investigator Global Assessment (IGA). They also had a smaller number of flares. Conclusion Adding apremilast to topical corticosteroid leads to better patient and physician‐perceived improvement and reduces the number of flares in hyperkeratotic hand eczema.