Recognizing the opponent: The consolidation of long-term social memory in zebrafish males

• Published in: Neurobiology of learning and memory 2024-07, Vol.212, p.107939, Article 107939
• Main Authors: Cavallino, Luciano, Florencia Scaia, María, Gabriela Pozzi, Andrea, Eugenia Pedreira, María
• Format: Article
• Language: English
• Subjects: Aggression - drug effects; Aggression - physiology; Aggressive behaviors; Animals; Behavior, Animal - drug effects; Behavior, Animal - physiology; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Long-term social memory; Male; Memory Consolidation - drug effects; Memory Consolidation - physiology; Memory, Long-Term - drug effects; Memory, Long-Term - physiology; NMDA receptor antagonist; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Recognition, Psychology - drug effects; Recognition, Psychology - physiology; Social Behavior; Zebrafish; Zebrafish - physiology
• ISSN: 1074-7427; 1095-9564; 1095-9564
• DOI: 10.1016/j.nlm.2024.107939

Recognizing and remembering another individual in a social context could be beneficial for individual fitness. Especially in agonistic encounters, remembering an opponent and the previous fight could allow for avoiding new conflicts. Considering this, we hypothesized that this type of social interaction forms a long-term recognition memory lasting several days. It has been shown that a second encounter 24 h later between the same pair of zebrafish males is resolved with lower levels of aggression. Here, we evaluated if this behavioral change could last for longer intervals and a putative mechanism associated with memory storage: the recruitment of NMDA receptors. We found that if a pair of zebrafish males fight and fight again 48 or 72 h later, they resolve the second encounter with lower levels of aggression. However, if opponents were exposed to MK-801 (NMDA receptor antagonist) immediately after the first encounter, they solved the second one with the same levels of aggression: that is, no reduction in aggressive behaviors was observed. These amnesic effect suggest the formation of a long-term social memory related to recognizing a particular opponent and/or the outcome and features of a previous fight.